Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer

被引:0
|
作者
Yupeng Jiang [1 ]
Yuyao Liu [2 ]
Hong Huang [3 ]
Tiantian Zhao [1 ]
Zengyi Zhao [1 ]
Yawen Gao [1 ]
机构
[1] The Second Xiangya Hospital,Department of Oncology
[2] Central South University,Department of Oncology
[3] The Affiliated Changsha Central Hospital,undefined
[4] Hengyang Medical School,undefined
[5] University of South China,undefined
[6] Guilin Medical University,undefined
关键词
RAS mutation; High microsatellite instability; Deficient mismatch repair; Colorectal cancer; Tumor microenvironment;
D O I
10.1007/s00262-024-03926-9
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Nonoperative Management of dMMR/MSI-H Colorectal Cancer following Neoadjuvant Immunotherapy: A Narrative Review
    Xiao, Binyi
    Yu, Jiehai
    Ding, Pei-Rong
    CLINICS IN COLON AND RECTAL SURGERY, 2023, 36 (06) : 378 - 384
  • [22] Analysis of HLA gene expression in patients with dMMR/MSI-H colorectal carcinoma resistant to immune checkpoint inhibitors.
    Lenz, Heinz-Josef
    Nicolaides, Theodore
    Elliott, Andrew
    Goldberg, Richard M.
    Marshall, John
    Lou, Emil
    Shields, Anthony Frank
    Sohal, Davendra
    Weinberg, Benjamin Adam
    Spetzler, David
    Abraham, Jim
    Xiu, Joanne
    Korn, Wolfgang Michael
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 : 202 - 202
  • [23] Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series
    Zhou, Chengjing
    Jiang, Ting
    Xiao, Yajie
    Wang, Qiaoxuan
    Zeng, Zhifan
    Cai, Peiqiang
    Zhao, Yongtian
    Zhao, Zhikun
    Wu, Dongfang
    Lin, Hanqing
    Sun, Chao
    Zhang, Rong
    Xiao, Weiwei
    Gao, Yuanhong
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [24] Safety and efficacy of pembrolizumab monotherapy in patients with advanced colorectal MSI-h/dMMR cancers.
    Michalaki, Vasiliki
    Polydorou, Andreas
    Dafnios, Nikolaos
    Theodosopoulos, Theodosios
    Vezakis, Antonios
    Iliakopoulos, Konstantinos
    Karandrea, Despina
    Papadimitriou, Christos
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [25] Prognostic role of systemic inflammatory markers in patients with metastatic MSI-h/dMMR colorectal cancer receiving immunotherapy.
    Bhamidipati, Deepak
    Raghav, Kanwal Pratap Singh
    Morris, Van K.
    Kopetz, Scott
    Kee, Bryan K.
    Johnson, Benny
    Willis, Jason
    Dasari, Arvind
    Morelli, Maria Pia
    Parseghian, Christine Megerdichian
    Lee, Michael Sangmin
    Le, Phat
    Shen, John Paul Y. C.
    Ludford, Kaysia
    Overman, Michael J.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [26] Serial ctDNA monitoring during immunotherapy (IO) in patients (pts) with MSI-H/dMMR advanced colorectal cancer (CRC)
    Somer, B.
    Mehler, S.
    Greene, H.
    Tauer, K.
    Somer, S.
    Grothey, A.
    ANNALS OF ONCOLOGY, 2023, 34 : S123 - S123
  • [27] Endometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment
    Song, Yunfeng
    Gu, Ye
    Hu, Xiang
    Wang, Mengfei
    He, Qizhi
    Li, Yiran
    ONCOTARGETS AND THERAPY, 2021, 14 : 4485 - 4497
  • [28] Does poor prognosis in African Americans with MSI-H colorectal cancer associate with altered immune markers
    Golconda, Umamaheshwari
    Sokol, Lena
    Shokrani, Babak
    Lee, Edward
    Hansel, Donna
    Fadare, Oluwole
    Patel, Sandip
    Nouraie, Mehdi
    Soleimani, Hooman
    Sharif, Zaki
    Afsari, Ali
    Daremipouran, Fareed
    Brim, Hassan
    Ashktorab, Hassan
    CANCER RESEARCH, 2017, 77
  • [29] An interpretable deep learning model for identifying the morphological characteristics of dMMR/MSI-H gastric cancer
    Zheng, Xueyi
    Jing, Bingzhong
    Zhao, Zihan
    Wang, Ruixuan
    Zhang, Xinke
    Chen, Haohua
    Wu, Shuyang
    Sun, Yan
    Zhang, Jiangyu
    Wu, Hongmei
    Huang, Dan
    Zhu, Wenbiao
    Chen, Jianning
    Cao, Qinghua
    Zeng, Hong
    Duan, Jinling
    Luo, Yuanliang
    Li, Zhicheng
    Lin, Wuhao
    Nie, Runcong
    Deng, Yishu
    Yun, Jingping
    Li, Chaofeng
    Xie, Dan
    Cai, Muyan
    Nie, Runcong
    ISCIENCE, 2024, 27 (03)
  • [30] MSI-H/dMMR and cancer immunotherapy: current state and future implications
    Rizzo, Alessandro
    Ricci, Angela Dalia
    Gadaleta-Caldarola, Gennaro
    EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT, 2021, 6 (06): : 345 - 347