Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model

被引：0
|
作者：
Li, Yeqi [1 ]
Ambati, Suresh [2 ]
Meagher, Richard B. [2 ]
Lin, Xiaorong [1 ]
机构：
[1] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
[2] Univ Georgia, Dept Genet, Athens, GA 30602 USA
来源：
NPJ VACCINES | 2025年 / 10卷 / 01期
关键词：
DNA VACCINE; POLYSACCHARIDE;
D O I：
10.1038/s41541-025-01079-z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with capsule adjuvant, vaccination with CDA1-LNPs protected the vast majority of mice from the otherwise lethal cryptococcosis. These results support the promise of mRNA-LNP vaccines against fungal diseases.
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页数：7
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