Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model

被引：0

作者：

Li, Yeqi ^{[1
]}

Ambati, Suresh ^{[2
]}

Meagher, Richard B. ^{[2
]}

Lin, Xiaorong ^{[1
]}

机构：

[1] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA

[2] Univ Georgia, Dept Genet, Athens, GA 30602 USA

来源：

NPJ VACCINES | 2025年 / 10卷 / 01期

关键词：

DNA VACCINE; POLYSACCHARIDE;

D O I：

10.1038/s41541-025-01079-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with capsule adjuvant, vaccination with CDA1-LNPs protected the vast majority of mice from the otherwise lethal cryptococcosis. These results support the promise of mRNA-LNP vaccines against fungal diseases.

引用

页数：7

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