Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress

被引：0
|
作者：
Haijing Zhao [1 ]
Nian Cao [2 ]
Qi Liu [1 ]
Yingyue Zhang [2 ]
Rui Jin [1 ]
Huiying Lai [2 ]
Li Zheng [4 ]
Honghong Zhang [5 ]
Yue Zhu [6 ]
Yuhan Ma [1 ]
Zengao Yang [2 ]
Zhengfeng Wu [1 ]
Weini Li [2 ]
Yuqi Liu [6 ]
Long Cheng [7 ]
Yundai Chen [1 ]
机构：
[1] the Sixth Medical Centre,Department of Cardiology
[2] Chinese PLA General Hospital,Medical School of Chinese PLA
[3] Chinese PLA General Hospital,The Key Laboratory of Geriatrics, Institute of Geriatric Medicine
[4] Beijing Institute of Geriatrics,Department of Clinical Laboratory
[5] Chinese Academy of Medical Sciences,School of Medicine
[6] Beijing Hospital/National Centre of Gerontology of National Health Commission,School of Medicine
[7] Beijing Institute of Biotechnology,Department of Biomedical Science
[8] Beijing Hospital,Department of Cardiology
[9] National Center of Gerontology,undefined
[10] Institute of Geriatric Medicine,undefined
[11] Chinese Academy of Medical Sciences,undefined
[12] Nankai University,undefined
[13] South China University of Technology,undefined
[14] Cedars-Sinai Cancer Institute,undefined
[15] Cedars-Sinai Medical Center,undefined
[16] National Key Laboratory of Kidney Diseases,undefined
[17] National Clinical Research Center of Geriatric Disease,undefined
[18] Beijing Key Laboratory of Chronic Heart Failure Precision Medicine,undefined
来源：
Journal of Translational Medicine | / 22卷 / 1期
关键词：
Vascular organoids; UBR5; TERT; Senescence; Oxidative stress;
D O I：
10.1186/s12967-024-05887-0
中图分类号：
学科分类号：
摘要：
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