Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress

被引：0

作者：

Haijing Zhao ^{[1
]}

Nian Cao ^{[2
]}

Qi Liu ^{[1
]}

Yingyue Zhang ^{[2
]}

Rui Jin ^{[1
]}

Huiying Lai ^{[2
]}

Li Zheng ^{[4
]}

Honghong Zhang ^{[5
]}

Yue Zhu ^{[6
]}

Yuhan Ma ^{[1
]}

Zengao Yang ^{[2
]}

Zhengfeng Wu ^{[1
]}

Weini Li ^{[2
]}

Yuqi Liu ^{[6
]}

Long Cheng ^{[7
]}

Yundai Chen ^{[1
]}

机构：

[1] the Sixth Medical Centre,Department of Cardiology

[2] Chinese PLA General Hospital,Medical School of Chinese PLA

[3] Chinese PLA General Hospital,The Key Laboratory of Geriatrics, Institute of Geriatric Medicine

[4] Beijing Institute of Geriatrics,Department of Clinical Laboratory

[5] Chinese Academy of Medical Sciences,School of Medicine

[6] Beijing Hospital/National Centre of Gerontology of National Health Commission,School of Medicine

[7] Beijing Institute of Biotechnology,Department of Biomedical Science

[8] Beijing Hospital,Department of Cardiology

[9] National Center of Gerontology,undefined

[10] Institute of Geriatric Medicine,undefined

[11] Chinese Academy of Medical Sciences,undefined

[12] Nankai University,undefined

[13] South China University of Technology,undefined

[14] Cedars-Sinai Cancer Institute,undefined

[15] Cedars-Sinai Medical Center,undefined

[16] National Key Laboratory of Kidney Diseases,undefined

[17] National Clinical Research Center of Geriatric Disease,undefined

[18] Beijing Key Laboratory of Chronic Heart Failure Precision Medicine,undefined

来源：

Journal of Translational Medicine | / 22卷 / 1期

关键词：

Vascular organoids; UBR5; TERT; Senescence; Oxidative stress;

D O I：

10.1186/s12967-024-05887-0

中图分类号：

学科分类号：

摘要：

引用

共 50 条

[31] Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5
Panfil, Amanda R.
Al-Saleem, Jacob
Howard, Cory M.
Shkriabai, Nikoloz
Kvaratskhelia, Mamuka
Green, Patrick L.
FRONTIERS IN MICROBIOLOGY, 2018, 9
[32] E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60
Subbaiah, V. K.
Zhang, Y.
Rajagopalan, D.
Abdullah, L. N.
Yeo-Teh, N. S. L.
Tomaic, V.
Banks, L.
Myers, M. P.
Chow, E. K.
Jha, S.
ONCOGENE, 2016, 35 (16) : 2062 - 2074
[33] E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60
V K Subbaiah
Y Zhang
D Rajagopalan
L N Abdullah
N S L Yeo-Teh
V Tomaić
L Banks
M P Myers
E K Chow
S Jha
Oncogene, 2016, 35 : 2062 - 2074
[34] Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B
Cojocaru, Marilena
Bouchard, Annie
Cloutier, Philippe
Cooper, Jeff J.
Varzavand, Katayoun
Price, David H.
Coulombe, Benoit
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (07) : 5012 - 5022
[35] E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
Duan, Chunyan
Li, Yue
Zhi, Haoyu
Tian, Yao
Huang, Zhengyun
Chen, Suping
Zhang, Yang
Liu, Qing
Zhou, Liang
Jiang, Xiaogang
Ullah, Kifayat
Guo, Qing
Liu, Zhaohui
Xu, Ying
Han, Junhai
Hou, Jiajie
O'Connor, Darran P.
Xu, Guo qiang
ACTA PHARMACOLOGICA SINICA, 2024, 45 (09) : 1793 - 1808
[36] E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Du, Yunyan
Yang, Zhangjian
Shi, Hao
Chen, Zhihan
Chen, Rong
Zhou, Fan
Peng, Xiaogang
Hong, Tao
Jiang, Liping
CELL DEATH & DISEASE, 2024, 15 (05):
[37] E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα
Leifeng Chen
Rongfa Yuan
Chongyu Wen
Tiande Liu
Qian Feng
Xueqiang Deng
Yunyan Du
Xiaogang Peng
Oncogene, 2021, 40 : 262 - 276
[38] E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1
Li, Jin
Zhang, Wei
Gao, Jian
Du, Min
Li, Huimin
Li, Mengge
Cong, Hui
Fang, Yuan
Liang, Yiyi
Zhao, Dan
Xiang, Gang
Ma, Xiaojing
Yao, Ming
Tu, Hong
Gan, Yu
FRONTIERS IN ONCOLOGY, 2021, 11
[39] E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα
Chen, Leifeng
Yuan, Rongfa
Wen, Chongyu
Liu, Tiande
Feng, Qian
Deng, Xueqiang
Du, Yunyan
Peng, Xiaogang
ONCOGENE, 2021, 40 (02) : 262 - 276
[40] Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
Hehl, Laura A.
Horn-Ghetko, Daniel
Prabu, J. Rajan
Vollrath, Ronnald
Vu, D. Tung
Berrocal, David A. Perez
Mulder, Monique P. C.
van Noort, Gerbrand J. van der Heden
Schulman, Brenda A.
NATURE CHEMICAL BIOLOGY, 2024, 20 (02) : 190 - +

← 1 2 3 4 5 →