Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress

被引：0

作者：

Haijing Zhao ^{[1
]}

Nian Cao ^{[2
]}

Qi Liu ^{[1
]}

Yingyue Zhang ^{[2
]}

Rui Jin ^{[1
]}

Huiying Lai ^{[2
]}

Li Zheng ^{[4
]}

Honghong Zhang ^{[5
]}

Yue Zhu ^{[6
]}

Yuhan Ma ^{[1
]}

Zengao Yang ^{[2
]}

Zhengfeng Wu ^{[1
]}

Weini Li ^{[2
]}

Yuqi Liu ^{[6
]}

Long Cheng ^{[7
]}

Yundai Chen ^{[1
]}

机构：

[1] the Sixth Medical Centre,Department of Cardiology

[2] Chinese PLA General Hospital,Medical School of Chinese PLA

[3] Chinese PLA General Hospital,The Key Laboratory of Geriatrics, Institute of Geriatric Medicine

[4] Beijing Institute of Geriatrics,Department of Clinical Laboratory

[5] Chinese Academy of Medical Sciences,School of Medicine

[6] Beijing Hospital/National Centre of Gerontology of National Health Commission,School of Medicine

[7] Beijing Institute of Biotechnology,Department of Biomedical Science

[8] Beijing Hospital,Department of Cardiology

[9] National Center of Gerontology,undefined

[10] Institute of Geriatric Medicine,undefined

[11] Chinese Academy of Medical Sciences,undefined

[12] Nankai University,undefined

[13] South China University of Technology,undefined

[14] Cedars-Sinai Cancer Institute,undefined

[15] Cedars-Sinai Medical Center,undefined

[16] National Key Laboratory of Kidney Diseases,undefined

[17] National Clinical Research Center of Geriatric Disease,undefined

[18] Beijing Key Laboratory of Chronic Heart Failure Precision Medicine,undefined

来源：

Journal of Translational Medicine | / 22卷 / 1期

关键词：

Vascular organoids; UBR5; TERT; Senescence; Oxidative stress;

D O I：

10.1186/s12967-024-05887-0

中图分类号：

学科分类号：

摘要：

引用

共 50 条

[1] Structure of the human UBR5 E3 ubiquitin ligase
Wang, Feng
He, Qing
Zhan, Wenhu
Yu, Ziqi
Finkin-Groner, Efrat
Ma, Xiaojing
Lin, Gang
Li, Huilin
STRUCTURE, 2023, 31 (05) : 541 - +
[2] Modulation of Myocardin Function by the Ubiquitin E3 Ligase UBR5
Hu, Guoqing
Wang, Xiaobo
Saunders, Darren N.
Henderson, Michelle
Russell, Amanda J.
Herring, B. Paul
Zhou, Jiliang
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (16) : 11800 - 11809
[3] Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer
Shearer, Robert F.
Iconomou, Mary
Watts, Colin K. W.
Saunders, Darren N.
MOLECULAR CANCER RESEARCH, 2015, 13 (12) : 1523 - 1532
[4] INVESTIGATING THE ROLE OF UBIQUITIN E3 LIGASE, UBR5, IN MYELOID MALIGNANCIES
Bean, Dalton
Weber, Kasidy
Winship, Carrie
Peters, Hendrick
Gavile, Catherine
Buckley, Shannon
EXPERIMENTAL HEMATOLOGY, 2023, 124 : S62 - S62
[5] Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD
Bethard, Jennifer Rutherford
Zheng, Hui
Roberts, Lawton
Eblen, Scott T.
JOURNAL OF PROTEOMICS, 2011, 75 (02) : 603 - 609
[6] Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
Shen, Qingya
Qiu, Zhiyu
Wu, Wenping
Zheng, Jimin
Jia, Zongchao
BIOLOGY OPEN, 2018, 7 (12):
[7] Identification of novel substrates of the UBR5 E3 ubiquitin ligase in ovarian cancer
Eblen, Scott T.
Bethard, Jennifer R.
Rogers, D. Ralph
Daoud, Abdelkader
Madan, Lalima K.
Ball, Lauren E.
CANCER RESEARCH, 2023, 83 (07)
[8] Research advancements on the involvement of E3 ubiquitin ligase UBR5 in gastrointestinal cancers
Qin, Rong
Fan, Xirui
Ding, Rui
Qiu, Yadan
Chen, Xujia
Liu, Yanting
Lin, Minjuan
Wang, Hui
HELIYON, 2024, 10 (09)
[9] The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma
Meissner, Barbara
Kridel, Robert
Lim, Raymond S.
Rogic, Sanja
Tse, Kane
Scott, David W.
Moore, Richard
Mungall, Andy J.
Marra, Marco A.
Connors, Joseph M.
Steidl, Christian
Gascoyne, Randy D.
BLOOD, 2013, 121 (16) : 3161 - 3164
[10] Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase
Matta-Camacho, Edna
Kozlov, Guennadi
Menade, Marie
Gehring, Kalle
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2012, 68 : 1158 - 1163

← 1 2 3 4 5 →