Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women

被引:0
|
作者
Hao, Ya-li [2 ]
Liu, Chun-miao [3 ]
Wang, Na [1 ]
Zhou, Rong-miao [1 ]
Wei, Ya-nan [2 ]
Bai, Xiao-shuang [2 ]
Huang, Xi [1 ]
机构
[1] Hebei Med Univ, Hosp 4, Dept Mol Biol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 4, Dept Reprod Med, Shijiazhuang 050011, Hebei, Peoples R China
[3] Fourth Hosp Shijiazhuang, Dept Obstet, Shijiazhuang 050035, Hebei, Peoples R China
关键词
Polycystic ovary syndrome; CYP19; gene; Single nucleotide polymorphism; Risk; Susceptibility; SINGLE-NUCLEOTIDE POLYMORPHISMS; AROMATASE; IDENTIFICATION; ORGANIZATION;
D O I
10.1186/s12920-025-02115-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose The objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene and the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women. Methods In this case-control study, a total of 340 women with PCOS and 340 matched healthy controls were recruited. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to investigate two SNPs (rs7176005 and rs6493497) in the 5'-flanking region of CYP19 gene exon 1. Results We observed a significant association of rs7176005 and rs6493497 with reduced risk of PCOS. Compared with CC genotype, a significant association of CT genotype (p = 0.019), TT genotype (p < 0.001) and combined CT + TT genotype (p < 0.001) with reduced risk of PCOS was observed. The result of linkage disequilibrium analysis showed that these two SNPs are in complete linkage disequilibrium (r(2) = 1). For rs7176005 SNP, compared with CC genotype, CT, TT and CT + TT genotypes reduced the risk of PCOS. The age, BMI-adjusted OR were 0.650 (95% CI = 0.460-0.917), 0.158 (95% CI = 0.066-0.376) and 0.545(95% CI = 0.391-0.759), respectively. Conclusions These findings highlight a significant association between CYP19 gene polymorphisms and PCOS susceptibility, implying potential protective effects of T and A alleles. Of course, the major limitation of this study is the sample size of the case-control study. Larger cohort studies are needed to confirm these findings and investigate the underlying causes.
引用
收藏
页数:6
相关论文
共 50 条
  • [31] Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk
    Kohan, Leila
    Zarei, Ali
    Fallahi, Sara
    Tabiee, Omid
    GENE, 2014, 539 (02) : 209 - 212
  • [32] Evaluation of the association between the CYP19 Tetranucleotide (TTTA) n Polymorphism and Polycystic Ovarian Syndrome(PCOS) in Han Chinese Women
    Hao, Cui-fang
    Zhang, Ning
    Qu, Qinglan
    Wang, Xiong
    Gu, Harvest F.
    Chen, Zi-jiang
    NEUROENDOCRINOLOGY LETTERS, 2010, 31 (03) : 370 - 374
  • [33] Delineating the role of single-nucleotide polymorphism of CYP19 gene on aromatase activity in South Indian women with polycystic ovary syndrome
    Pravesh Hegde
    Shilpa S. Shetty
    Prasanna Kumar Shetty
    Lakshmi Manjeera
    D. Prashanth Shetty
    Suchetha Kumari
    Journal of Genetic Engineering and Biotechnology, 21
  • [34] Delineating the role of single-nucleotide polymorphism of CYP19 gene on aromatase activity in South Indian women with polycystic ovary syndrome
    Hegde, Pravesh
    Shetty, Shilpa S.
    Shetty, Prasanna Kumar
    Manjeera, Lakshmi
    Shetty, D. Prashanth
    Kumari, Suchetha
    JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, 2023, 21 (01)
  • [35] Aromatase gene (CYP19) haplotype and insulin resistance are independently associated with polycystic ovary syndrome risk in both girls and young women
    Petry, CJ
    Ong, KK
    Michelmore, K
    Artigas, S
    Wingate, DL
    de Zegher, F
    Ibáñez, L
    Dunger, DB
    DIABETOLOGIA, 2004, 47 : A190 - A191
  • [36] CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women
    Wang, Ledan
    Lu, Xiaosheng
    Wang, Danhan
    Qu, Wanglei
    Li, Wenju
    Xu, Xiaowen
    Huang, Qiusui
    Han, Xueying
    Lv, Jieqiang
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2014, 46 : e103 - e103
  • [37] CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women
    Ledan Wang
    Xiaosheng Lu
    Danhan Wang
    Wanglei Qu
    Wenju Li
    Xiaowen Xu
    Qiusui Huang
    Xueying Han
    Jieqiang Lv
    Experimental & Molecular Medicine, 2014, 46 : e103 - e103
  • [38] The relationship between the CYP19 alleles rs727479A/C, rs700518A/G, and rs700519C/T and pregnancy outcome after assisted reproductive technology in patients with polycystic ovary syndrome in a Chinese population: A population-based study
    Dou, Qian
    Tan, Li
    Ma, Li-Ying
    Sun, Ying-Pu
    KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2017, 33 (11): : 558 - 566
  • [39] Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India
    Chaudhary, Hiral
    Patel, Jalpa
    Jain, Nayan K.
    Panchal, Sonal
    Laddha, Naresh
    Joshi, Rushikesh
    BMC MEDICAL GENOMICS, 2023, 16 (01)
  • [40] Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome
    Wu, Han
    Wang, Hui
    Sun, Lixia
    Liu, Mengchen
    Wang, Haoran
    Sun, Xianchang
    Zhang, Wenjuan
    DIABETES METABOLIC SYNDROME AND OBESITY, 2024, 17 : 1749 - 1760