Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women

被引:0
|
作者
Hao, Ya-li [2 ]
Liu, Chun-miao [3 ]
Wang, Na [1 ]
Zhou, Rong-miao [1 ]
Wei, Ya-nan [2 ]
Bai, Xiao-shuang [2 ]
Huang, Xi [1 ]
机构
[1] Hebei Med Univ, Hosp 4, Dept Mol Biol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 4, Dept Reprod Med, Shijiazhuang 050011, Hebei, Peoples R China
[3] Fourth Hosp Shijiazhuang, Dept Obstet, Shijiazhuang 050035, Hebei, Peoples R China
关键词
Polycystic ovary syndrome; CYP19; gene; Single nucleotide polymorphism; Risk; Susceptibility; SINGLE-NUCLEOTIDE POLYMORPHISMS; AROMATASE; IDENTIFICATION; ORGANIZATION;
D O I
10.1186/s12920-025-02115-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose The objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene and the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women. Methods In this case-control study, a total of 340 women with PCOS and 340 matched healthy controls were recruited. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to investigate two SNPs (rs7176005 and rs6493497) in the 5'-flanking region of CYP19 gene exon 1. Results We observed a significant association of rs7176005 and rs6493497 with reduced risk of PCOS. Compared with CC genotype, a significant association of CT genotype (p = 0.019), TT genotype (p < 0.001) and combined CT + TT genotype (p < 0.001) with reduced risk of PCOS was observed. The result of linkage disequilibrium analysis showed that these two SNPs are in complete linkage disequilibrium (r(2) = 1). For rs7176005 SNP, compared with CC genotype, CT, TT and CT + TT genotypes reduced the risk of PCOS. The age, BMI-adjusted OR were 0.650 (95% CI = 0.460-0.917), 0.158 (95% CI = 0.066-0.376) and 0.545(95% CI = 0.391-0.759), respectively. Conclusions These findings highlight a significant association between CYP19 gene polymorphisms and PCOS susceptibility, implying potential protective effects of T and A alleles. Of course, the major limitation of this study is the sample size of the case-control study. Larger cohort studies are needed to confirm these findings and investigate the underlying causes.
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页数:6
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