Emestrin-type epipolythiodioxopiperazines from Aspergillus nidulans with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways

被引：0
|
作者：
Li, Pengkun [1 ]
Li, Qin [1 ]
Fu, Aimin [1 ]
Xiao, Yang [1 ]
Chen, Chunmei [1 ]
Zhu, Hucheng [1 ]
Qi, Changxing [1 ]
Wei, Wei [2 ]
Zhou, Yuan [1 ]
Zhang, Yonghui [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
[2] China Natl Ctr Biotechnol Dev, Beijing 100039, Peoples R China
来源：
NATURAL PRODUCTS AND BIOPROSPECTING | 2025年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
<italic>Aspergillus nidulans</italic>; Epipolythiodioxopiperazines; Thioethanothio bridge; Structural elucidation; Cytotoxicity; NATURAL-PRODUCTS;
D O I：
10.1007/s13659-025-00498-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C-G (1-5), along with two known ETPs, prenylemestrin A (6) and prenylemestrin B (7), were obtained from Aspergillus nidulans. Their structures were characterized by spectroscopic data, X-ray crystallographic data, ECD comparisons and calculations. Prenylemestrins C-G (1 - 5) represent a rare class of ETPs, characterized by a 2,5-dithia-7,9-diazabicyclo[4.2.2]decane-8,10-dione core involving a hemiterpene moiety. Notably, compound 6 exhibited moderate cytotoxicity, inducing G2/M cell cycle arrest and apoptosis of L1210 cells by regulating the PI3K/AKT signaling pathway and mitochondrial apoptotic mechanisms.
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页数：12
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