Emestrin-type epipolythiodioxopiperazines from Aspergillus nidulans with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways

被引：0

作者：

Li, Pengkun ^{[1
]}

Li, Qin ^{[1
]}

Fu, Aimin ^{[1
]}

Xiao, Yang ^{[1
]}

Chen, Chunmei ^{[1
]}

Zhu, Hucheng ^{[1
]}

Qi, Changxing ^{[1
]}

Wei, Wei ^{[2
]}

Zhou, Yuan ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] China Natl Ctr Biotechnol Dev, Beijing 100039, Peoples R China

来源：

NATURAL PRODUCTS AND BIOPROSPECTING | 2025年 / 15卷 / 01期

基金：

中国国家自然科学基金;

关键词：

<italic>Aspergillus nidulans</italic>; Epipolythiodioxopiperazines; Thioethanothio bridge; Structural elucidation; Cytotoxicity; NATURAL-PRODUCTS;

D O I：

10.1007/s13659-025-00498-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C-G (1-5), along with two known ETPs, prenylemestrin A (6) and prenylemestrin B (7), were obtained from Aspergillus nidulans. Their structures were characterized by spectroscopic data, X-ray crystallographic data, ECD comparisons and calculations. Prenylemestrins C-G (1 - 5) represent a rare class of ETPs, characterized by a 2,5-dithia-7,9-diazabicyclo[4.2.2]decane-8,10-dione core involving a hemiterpene moiety. Notably, compound 6 exhibited moderate cytotoxicity, inducing G2/M cell cycle arrest and apoptosis of L1210 cells by regulating the PI3K/AKT signaling pathway and mitochondrial apoptotic mechanisms.

引用

页数：12

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