The characteristics of heat transfer and fluid flow of twisted spiral tubes with different pitches and depths have been investigated experimentally with respect to a conventional tube (smooth tube) as a particular reference. The effects of the twisted spiral pitch ratios, S/Dhy, depth ratios, H/Dhy, Reynolds number and flow arrangement on the thermal performance of a twisted spiral tube heat exchanger are investigated. Three twisted spiral tubes with different pitches, S, of 3.9, 5.2 and 8.2 mm corresponding to twisted spiral pitch ratios, S/Dhy, of 0.278, 0.372 and 0.586; besides three twisted spiral tubes at different depths, H, of 0.6, 0.95, and 1.15 mm corresponding to twisted spiral height ratio, H/Dhy, of 0.043, 0.068 and 0.082 are experimentally examined in this study. The Reynolds number, Re, ranges in both inner tube side and annular side are 5000-50,000 and 1400-10,400, respectively. The results revealed that the twisted spiral pitch ratios S/Dhy of the 0.278achieved an enhancement of Nu by 38% compare to the smooth tube with a corresponding increase of 33.2% in the f. Also, the twisted spiral depths ratios, H/Dhy, of 0.082 achieved higher Nu by 44.9%, compared to the smooth tube with a corresponding increase of 36.4% in the f. The thermal performance criteria reached 1.93 and 2.03 at S/Dhy of 0.278 and H/Dhy of 0.082, respectively. New correlations to expect Nuc and fc were predicted.