Isolation, purification and identification of the spermicidal active compound from neem oil

被引：0
|
作者：
Yin, Zhongqiong [1 ,2 ]
Gao, Ping [1 ]
Gao, Rong [1 ]
Jiang, Dehong [1 ]
Liu, Kun [1 ]
Liu, Shigui [1 ]
机构：
[1] Lab. for Biol. Resource, Coll. of Life Sci., Sichuan Univ., Chengdu 610064, China
[2] Dept. of Veterinary Med., Southwest Agric. Univ., Chongqing 402460, China
来源：
High Technology Letters | 2004年 / 10卷 / 03期
关键词：
Bioassay - Fractionation - Purification - Spectroscopic analysis;
D O I：
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中图分类号：
学科分类号：
摘要：
Bioassay-directed fractionation of the chloroform extract of the neem oil has resulted in the isolation of new esters derivatives named 2-octadecanoic acid-4-palmitic acid-2,4-pentanediyl ester (compound 1). Its structure is deduced on the basis of spectroscopic evidence. The test of in vitro spermicidal activity of the compound 1 shows that the compound 1 can kill all sperms of Kunming mice in vitro in less than 20 sec at the concentration of 2 mg/ml.
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页码：44 / 46
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