Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase

被引：0
|
作者：
Lewis, Deborah A. [1 ]
Bebenek, Katarzyna [1 ]
Beard, William A. [1 ]
Wilson, Samuel H. [1 ]
Kunkel, Thomas A. [1 ]
机构：
[1] Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, United States
来源：
Journal of Biological Chemistry | / 274卷 / 46期
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：32924 / 32930
相关论文
共 50 条
  • [31] Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous
    Wilson, JE
    Wright, LL
    Martin, JL
    Haire, SE
    Ray, PH
    Painter, GR
    Furman, PA
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 11 (01): : 20 - 30
  • [32] Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase
    Sharma, PL
    Nurpeisov, V
    Hernandez-Santiago, B
    Beltran, T
    Schinazi, RF
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (09) : 895 - 919
  • [33] Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type I reverse transcriptase
    Pelemans, H
    Esnouf, RM
    Jonckheere, H
    De Clercq, E
    Balzarini, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) : 34234 - 34239
  • [34] Human antibodies responsible for binding inhibition and polymerization inhibition of human immunodeficiency virus type 1 reverse transcriptase
    Odawara, F
    Sano, K
    Otake, T
    Okubo, S
    Nakano, T
    Takasaki, T
    Ueba, N
    Misaki, H
    Nakai, M
    JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 199 (02) : 175 - 184
  • [35] Initiation of minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase
    Vaccaro, JA
    Singh, HA
    Anderson, KS
    BIOCHEMISTRY, 1999, 38 (48) : 15978 - 15985
  • [36] Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target
    Srivastava, S.
    Sluis-Cremer, N.
    Tachedjian, G.
    CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (15) : 1879 - 1894
  • [37] Studies on the effects of truncating α-helix E′ of p66 human immunodeficiency virus type 1 reverse transcriptase on template-primer binding and fidelity of DNA synthesis
    Menéndez-Arias, L
    BIOCHEMISTRY, 1998, 37 (47) : 16636 - 16644
  • [38] The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication
    Van Cor-Hosmer, Sarah K.
    Daddacha, Waaqo
    Kelly, Z.
    Tsurumi, Amy
    Kennedy, Edward M.
    Kim, Baek
    VIROLOGY, 2012, 422 (02) : 393 - 401
  • [39] Structural requirements for the binding of tRNA3Lys to reverse transcriptase of the human immunodeficiency virus type 1
    J. Biol. Chem., 40 (23867-23874):
  • [40] INFECTIOUS POTENTIAL OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 REVERSE-TRANSCRIPTASE MUTANTS WITH ALTERED INHIBITOR SENSITIVITY
    LARDER, BA
    KEMP, SD
    PURIFOY, DJM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) : 4803 - 4807
12345