Synthesis, reactions and antibacterial activity of 3-acetyl[1,2,4] triazolo[3,4-a]isoquinoline derivatives using chitosan as heterogeneous catalyst under microwave irradiation

被引：0

作者：

Hassaneen H.M. ^{[1
]}

Hassaneen H.M.E. ^{[1
]}

Mohammed Y.S. ^{[1
]}

Pagni R.M. ^{[2
]}

机构：

[1] Department of Chemistry, Faculty of Science, Cairo University, Giza

[2] Department of Chemistry, University of Tennessee, Knoxville

来源：

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | 2011年 / 66卷 / 03期

关键词：

Chitosan; Cycloaddition reaction; Enaminones; Hydrazinolysis; Hydrazonoyl chlorides; Hydroximoyl chloride; 1,2,4]Triazolo[3,4-a]isoquinoline;

D O I：

10.1515/znb-2011-0313

中图分类号：

学科分类号：

摘要：

3-Acetyl[1,2,4]triazolo[3,4-a]isoquinolines were prepared using chitosan as a catalyst. These compounds were used to prepare a novel series of enaminones 5, and their reactions with hydrazonoyl halides 1 and 11 gave triazoloisoquinolines 8 and 13, respectively, with a carbonylpyrazole side chain. Hydrazinolysis of 8 and 13 gave the pyrazolopyridazines 10 and pyrazolopyridazinones 14. Reaction of 5 with hydroximoyl halides 15 led to triazoloisoquinoline 16 with a carbonylisoxazole side chain. Antibacterial effects of compounds 8 and 10 were studied. © 2011 Verlag der Zeitschrift für Naturforschung.

引用

页码：299 / 310

页数：11

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