Synthesis, reactions and antibacterial activity of 3-acetyl[1,2,4] triazolo[3,4-a]isoquinoline derivatives using chitosan as heterogeneous catalyst under microwave irradiation

被引：0
|
作者：
Hassaneen H.M. [1 ]
Hassaneen H.M.E. [1 ]
Mohammed Y.S. [1 ]
Pagni R.M. [2 ]
机构：
[1] Department of Chemistry, Faculty of Science, Cairo University, Giza
[2] Department of Chemistry, University of Tennessee, Knoxville
来源：
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | 2011年 / 66卷 / 03期
关键词：
Chitosan; Cycloaddition reaction; Enaminones; Hydrazinolysis; Hydrazonoyl chlorides; Hydroximoyl chloride; 1,2,4]Triazolo[3,4-a]isoquinoline;
D O I：
10.1515/znb-2011-0313
中图分类号：
学科分类号：
摘要：
3-Acetyl[1,2,4]triazolo[3,4-a]isoquinolines were prepared using chitosan as a catalyst. These compounds were used to prepare a novel series of enaminones 5, and their reactions with hydrazonoyl halides 1 and 11 gave triazoloisoquinolines 8 and 13, respectively, with a carbonylpyrazole side chain. Hydrazinolysis of 8 and 13 gave the pyrazolopyridazines 10 and pyrazolopyridazinones 14. Reaction of 5 with hydroximoyl halides 15 led to triazoloisoquinoline 16 with a carbonylisoxazole side chain. Antibacterial effects of compounds 8 and 10 were studied. © 2011 Verlag der Zeitschrift für Naturforschung.
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页码：299 / 310
页数：11
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