Parametrization of dose profiles of therapeutic minibeams of protons, 4 He, 12 C, and 16O

被引：0

作者：

Savenkov, Savva ^{[1
]}

Svetlichnyi, Alexandr ^{[1
]}

Pshenichnov, Igor ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Nucl Res, 60 Letia Oktyabrya,7a, Moscow 117312, Russia

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2025年 / 559卷

基金：

俄罗斯科学基金会;

关键词：

Minibeam radiation therapy; Monte Carlo modeling; Dose distributions; MULTIPLE-SCATTERING; RADIATION-THERAPY; SCANNED PROTON; ION THERAPY; BEAM; GEANT4; CARBON; RADIOTHERAPY; OPTIMIZATION; SIMULATIONS;

D O I：

10.1016/j.nimb.2024.165604

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Single minibeams of protons, 4 He, 12 C and 16 O in water were modeled with Geant4, and their dose distributions were parameterized with double-Gauss-Rutherford (DGR) functions. Dose distributions from arrays of 16 parallel minibeams centered on a rectangular or hexagonal grid were constructed from the parameterized minibeam profiles to simulate the lateral convergence of the minibeams resulting in a homogeneous dose field in the target tumor volume. Peak-to-valley dose ratios (PVDR) and dose-volume histograms (DVH) were calculated for the parameterized dose distributions and compared with those obtained directly from Geant4 modeling of minibeam arrays. The similarity of the results obtained by these two methods suggests that the fast calculation of dose profiles of minibeam arrays based on the DGR parameterizations proposed in this work can replace the time-consuming MC modeling in future preclinical studies and also in the development of treatment planning systems for minibeam therapy.

引用

页数：14

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