Parametrization of dose profiles of therapeutic minibeams of protons, 4 He, 12 C, and 16O

被引：0

作者：

Savenkov, Savva ^{[1
]}

Svetlichnyi, Alexandr ^{[1
]}

Pshenichnov, Igor ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Nucl Res, 60 Letia Oktyabrya,7a, Moscow 117312, Russia

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2025年 / 559卷

基金：

俄罗斯科学基金会;

关键词：

Minibeam radiation therapy; Monte Carlo modeling; Dose distributions; MULTIPLE-SCATTERING; RADIATION-THERAPY; SCANNED PROTON; ION THERAPY; BEAM; GEANT4; CARBON; RADIOTHERAPY; OPTIMIZATION; SIMULATIONS;

D O I：

10.1016/j.nimb.2024.165604

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Single minibeams of protons, 4 He, 12 C and 16 O in water were modeled with Geant4, and their dose distributions were parameterized with double-Gauss-Rutherford (DGR) functions. Dose distributions from arrays of 16 parallel minibeams centered on a rectangular or hexagonal grid were constructed from the parameterized minibeam profiles to simulate the lateral convergence of the minibeams resulting in a homogeneous dose field in the target tumor volume. Peak-to-valley dose ratios (PVDR) and dose-volume histograms (DVH) were calculated for the parameterized dose distributions and compared with those obtained directly from Geant4 modeling of minibeam arrays. The similarity of the results obtained by these two methods suggests that the fast calculation of dose profiles of minibeam arrays based on the DGR parameterizations proposed in this work can replace the time-consuming MC modeling in future preclinical studies and also in the development of treatment planning systems for minibeam therapy.

引用

页数：14

共 50 条

[21] Tetrahedral 4α and 12C + α cluster structures in 16O
Kanada-En'yo, Yoshiko
PHYSICAL REVIEW C, 2017, 96 (03)
[22] 16O(e,e′α)12C measurements and the 12C(α,γ)16O astrophysical reaction rate
Potterveld, D. H.
Filippone, B. W.
Holt, R. J.
Friscic, I.
PHYSICAL REVIEW C, 2024, 110 (03)
[23] Breakup of 16O nucleus onto C and He isotopes by protons at incident momentum of 3.25A GeV/c
Olimov, Kosim
Olimov, Khusniddin K.
Lutpullaev, Sagdulla L.
Bazarov, Erkin Kh.
Olimov, Alisher K.
Lugovoi, Vladimir V.
Gulamov, K. G.
Navotny, Vadim Sh.
INTERNATIONAL JOURNAL OF MODERN PHYSICS E-NUCLEAR PHYSICS, 2016, 25 (03)
[24] )) SCATTERING OF PROTONS ON 12C 16O AND NUCLEI WITH MASS NUMBERS FROM 27 TO 30
ANTROPOV, AE
GRIDNEV, KA
ZARUBIN, PP
KUDRYASH.VI
ORLOV, BN
PLAVKO, AV
STEPANOV, IV
IZVESTIYA AKADEMII NAUK SSSR SERIYA FIZICHESKAYA, 1968, 32 (12): : 2031 - &
[25] Impact of 16O(e, e′ α)12C measurements on the 12C(α, γ)16O astrophysical reaction rate
Holt, R. J.
Filippone, B. W.
PHYSICAL REVIEW C, 2019, 100 (06)
[26] Analysis of refraction effects in the 4He + 15N, 16O and 16O + 12C scattering in S-matrix model with Regge poles
Kuznichenko, A.V.
Pilipenko, V.V.
Onishenko, G.M.
Dem'yanova, A.S.
Izvestiya Akademii Nauk. Ser. Fizicheskaya, 2002, 66 (05): : 701 - 707
[27] α+12C rotational bands in 16O
Katsuma, M.
INPC 2013 - INTERNATIONAL NUCLEAR PHYSICS CONFERENCE, VOL. 1, 2014, 66
[28] Heavy Cluster Knockout Reaction 16O(12C, 212C)4He and the Nature of the 12C-12C Interaction Potential
Joshi, B. N.
Jain, Arun K.
Gupta, Y. K.
Biswas, D. C.
Saxena, A.
John, B. V.
Danu, L. S.
Vind, R. P.
Choudhury, R. K.
PHYSICAL REVIEW LETTERS, 2011, 106 (02)
[29] Dosimetric comparisons of 1H, 4He, 12C and 16O ion beams at HIT
Tessonnier, T.
Mairani, A.
Brons, S.
Haberer, T.
Debus, J.
Parodi, K.
RADIOTHERAPY AND ONCOLOGY, 2016, 119 : S271 - S271
[30] Direct Measurement of the 4He(12C, 16O)γ Total Cross Section Near Stellar Energies
Fujita, Kunihiro
Yamaguchi, Hiroyuki
Ban, Tadahiko
Hamamoto, Kenichi
Narikiyo, Yoshihiro
Tao, Nariaki
Sagara, Kenshi
CGS15 - CAPTURE GAMMA-RAY SPECTROSCOPY AND RELATED TOPICS, 2015, 93

← 1 2 3 4 5 →