Self-assembled nanocages for hydrophilic guest molecules

被引：0

作者：

Jones, Marie-Christine ^{[2
]}

Tewari, Pankaj ^{[2
]}

Blei, Claudia ^{[2
]}

Hales, Kelly ^{[3
]}

Pochan, Darrin J. ^{[3
]}

Leroux, Jean-Christophe ^{[1
,2
]}

机构：

[1] Canada Research Chair in Drug Delivery, Downtown Station, P.O. Box 6128, Montreal, Que. H3C 3J7, Canada

[2] Faculty of Pharmacy, Université de Montréal, Downtown Station, P.O. Box 6128, Montreal, Que. H3C 3J7, Canada

[3] Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19176, United States

来源：

Journal of the American Chemical Society | 2006年 / 128卷 / 45期

关键词：

Reverse polymeric micelles are obtained following the association of polymeric amphiphiles in apolar media. To this date; reports of pharmaceutical applications for such micelles have been scarce; mainly because these systems have been studied in solvents that are not suitable for medical use. Here; alkylated star-shaped poly(glycerol methacrylate) polymers have been proposed in the design of oil-soluble reverse polymeric micelles. Micellar behavior was studied in various apolar solvents; including ethyl oleate; a pharmaceutically acceptable vehicle. The polymers were shown to assemble into spherical nanostructures (<40 nm) as determined by cryogenic transmission electron microscopy and atomic force microscopy studies. Interestingly; the reverse micelles were able to encapsulate various peptides/proteins (vasopressin; myoglobin; and albumin) in substantial amounts and facilitate their solubilization in oil. The nature of both the polymer used in micelle formation and the guest molecules was found to influence the ability of the micelle to interact with hydrophilic compounds. © 2006 American Chemical Society;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Journal article (JA)

引用

页码：14599 / 14605

共 50 条

[31] Nanoscale Friction of Hydrophilic and Hydrophobic Self-Assembled Monolayers in Water
Quanpeng Yang
Warren Nanney
Xiaoli Hu
Tao Ye
Ashlie Martini
Tribology Letters, 2020, 68
[32] Generation and characterization of self-assembled protein nanocages based on β-carboxysomes in Escherichia coli
Gao, Ruimin
Zhang, Xian-En
Li, Feng
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 53 (07) : 943 - 949
[33] Self-assembled nanocages of anthracene by liquid-liquid interface recrystallization technique
Hawaldar, R
Jadkar, S
Kale, B
Mulik, U
Sathaye, S
Amalnerkar, D
CHEMISTRY LETTERS, 2006, 35 (01) : 26 - 27
[34] Self-assembled capsule with guest encapsulation directed to supramolecular gyroscope
Kobayashi, Kenji
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
[35] Guest-encapsulation behavior in a self-assembled heterodimeric capsule
Kitagawa, Hitomi
Kawahata, Masatoshi
Kitagawa, Ryosuke
Yamada, Yoshifumi
Yamanaka, Masamichi
Yamaguchi, Kentaro
Kobayashi, Kenji
TETRAHEDRON, 2009, 65 (35) : 7234 - 7239
[36] Selective guest recognition by a self-assembled paramagnetic cage complex
Turega, Simon
Whitehead, Martina
Hall, Benjamin R.
Haddow, Mairi F.
Hunter, Christopher A.
Ward, Michael D.
CHEMICAL COMMUNICATIONS, 2012, 48 (22) : 2752 - 2754
[37] Self-assembled host-guest materials for organic electroluminescence
Anzenbacher, Pavel, Jr.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233
[38] Observation of self-assembled monolayers on diamond-like carbon films: agglomeration of self-assembled FDTS molecules
Choi, Junho
Sakurai, Kenichi
Kato, Takahisa
SURFACE AND INTERFACE ANALYSIS, 2010, 42 (6-7) : 1373 - 1376
[39] Self-Assembled Organic Microtubes from Amphiphilic Molecules
Lee, Ho Yong
Nam, Seong Ryong
Hong, Jong-In
CHEMISTRY-AN ASIAN JOURNAL, 2009, 4 (02) : 226 - 235
[40] Oriented self-assembled monolayers of bifunctional molecules on InAs
Stine, R.
Petrovykh, D. Y.
JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 2009, 172 (1-3) : 42 - 46

← 1 2 3 4 5 →