Self-assembled nanocages for hydrophilic guest molecules

被引：0

作者：

Jones, Marie-Christine ^{[2
]}

Tewari, Pankaj ^{[2
]}

Blei, Claudia ^{[2
]}

Hales, Kelly ^{[3
]}

Pochan, Darrin J. ^{[3
]}

Leroux, Jean-Christophe ^{[1
,2
]}

机构：

[1] Canada Research Chair in Drug Delivery, Downtown Station, P.O. Box 6128, Montreal, Que. H3C 3J7, Canada

[2] Faculty of Pharmacy, Université de Montréal, Downtown Station, P.O. Box 6128, Montreal, Que. H3C 3J7, Canada

[3] Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19176, United States

来源：

Journal of the American Chemical Society | 2006年 / 128卷 / 45期

关键词：

Reverse polymeric micelles are obtained following the association of polymeric amphiphiles in apolar media. To this date; reports of pharmaceutical applications for such micelles have been scarce; mainly because these systems have been studied in solvents that are not suitable for medical use. Here; alkylated star-shaped poly(glycerol methacrylate) polymers have been proposed in the design of oil-soluble reverse polymeric micelles. Micellar behavior was studied in various apolar solvents; including ethyl oleate; a pharmaceutically acceptable vehicle. The polymers were shown to assemble into spherical nanostructures (<40 nm) as determined by cryogenic transmission electron microscopy and atomic force microscopy studies. Interestingly; the reverse micelles were able to encapsulate various peptides/proteins (vasopressin; myoglobin; and albumin) in substantial amounts and facilitate their solubilization in oil. The nature of both the polymer used in micelle formation and the guest molecules was found to influence the ability of the micelle to interact with hydrophilic compounds. © 2006 American Chemical Society;

D O I：

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学科分类号：

摘要：

Journal article (JA)

引用

页码：14599 / 14605

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