Peptide-sugar ligation catalyzed by transpeptidase sortase: A facile approach to neoglycoconjugate synthesis

被引：0
|
作者：
Samantaray, Sharmishtha [1 ]
Marathe, Uttara [1 ]
Dasgupta, Sayani [1 ]
Nandicoori, Vinay K. [1 ]
Roy, Rajendra P. [1 ]
机构：
[1] National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 07期
关键词：
Glycoconjugate synthesis involving sugar and polypeptide remains a formidable challenge. Here we report a novel enzymatic method involving an unprecedented sortase-catalyzed transamidation reaction for site-specific engineering of sugars into native proteins. We show that sugars appended with a 6-aminohexose moiety can be efficiently ligated to peptides and proteins encoded with a LPXTG sortase recognition sequence. This robust reaction provides an elegant and simple approach for generating neoglycoproteins with an amide-linked sugar moiety at the carboxy terminus. Copyright © 2008 American Chemical Society;
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Journal article (JA)
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页码：2132 / 2133
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