The difference properties of porcine acellular dermal matrix crosslinked by epoxy compound and carbodiimide

被引：0
|
作者：
Dan, Nian-Hua [1 ,3 ]
Dan, Wei-Hua [1 ,2 ]
Guan, Lin-Bo [3 ]
Lin, Hai [1 ]
Wang, Kang-Jian [1 ]
机构：
[1] National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China
[2] Research Center of Biomedicine Engineering, Chengdu 610065, China
[3] Jiangyin Benshine Bio-technology Co. Ltd., Jiangyin 214432, China
来源：
Gongneng Cailiao/Journal of Functional Materials | 2009年 / 40卷 / 08期
关键词：
Cell culture - Cytotoxicity - Extraction - Glycerol;
D O I：
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中图分类号：
学科分类号：
摘要：
Porcine acellular dermal matrix (pADM) was crosslinked by epoxy compound (glycerol polyglycidyl ether)and carbodiimide (EDC) respectively. The properties of pADM, EDC-pADM, EC(GPE)-pADM were mensurated, such as efficiency of crosslinking, XPS, acute toxicity and cytotoxicity. It was showed that glycerol polyglycidyl ether (GPE) was less effective than EDC, hydrophilic performance of EC-pADM was better than EDC-pADM. The acute toxicity of extraction of EC-pADM on mice by mouth did not appeared whereas EC-pADM did. The cytotoxicity of extraction botainted from them respectively weren't observed in L-929 fibroblasts cultivated experiment. It was concluded that the properties of EC-pADM was better than EDC-pADM.
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页码：1352 / 1354
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