Etiolated-green tea attenuates colonic barrier dysfunction and inflammation in high-fat diet-induced mice by modulating gut microbiota

被引：0
|
作者：
Tian, Baoming [1 ]
Pan, Yizhu [1 ]
Zhang, Xiangchun [1 ]
Wu, Yuanyuan [2 ]
Luo, Xudong [3 ]
Yang, Kai [1 ]
机构：
[1] College of Food Science and Technology, Zhejiang University of Technology, Huzhou,313299, China
[2] Department of Tea Science, Zhejiang University, Hangzhou,310058, China
[3] Sichuan Three MT. TEA-INDUSTRY Co., Ltd, Guangyuan,628200, China
来源：
Food Research International | 2024年 / 197卷
关键词：
Colonic barrier dysfunction and inflammation arising from dysbiosis gut microbiota (GM) are strongly associated with a high-fat diet (HFD). Yellow leaf green tea (YLGT); a novel variety of etiolated-green tea; improving the intestinal barrier and inflammation is related to the regulation of GM disorders. To explore the ameliorative mechanism of YLGT; mice were fed an HFD with or without YLGT at doses of 150; 300; and 450 mg kg−1 for 12 weeks. YLGT rectified the GM imbalance; enriched short-chain fatty acid (SCFA)-producing bacteria and gut SCFA contents; activated G protein-coupled receptors; inhibited TLR4/NF-κB signaling pathway; strengthened the tight junction; and repaired the damaged intestinal barrier. The fecal microbiota transplantation experiment further confirmed that the GM was a key element in the anti-obesity and anti-intestinal inflammation effect of YLGT. YLGT has great promise in attenuating obesity-induced intestinal dysfunction. This research provides novel insights into the new mechanism of YLGT on HFD-induced obesity. © 2024 Elsevier Ltd;
D O I：
10.1016/j.foodres.2024.115192
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