Antibacterial adhesive based on oxidized tannic acid-chitosan for rapid hemostasis

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作者：
Khosravi, Z. [1 ]
Kharaziha, M. [1 ]
Goli, R. [1 ]
Karimzadeh, F. [1 ]
机构：
[1] Department of Materials Engineering, Isfahan University of Technology, Isfahan,84156-83111, Iran
来源：
Carbohydrate Polymers | 2024年 / 333卷
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摘要：
Currently, bacterial infections and bleeding interfere with wound healing, and multifunctional hydrogels with appropriate blood homeostasis, skin adhesion, and antibacterial activity are desirable. In this study, chitosan-based hydrogels were synthesized using oxidized tannic acid (OTA) and Fe3+ as cross-linkers (CS-OTA-Fe) by forming covalent, non-covalent, and metal coordination bonds between Fe3+ and OTA. Our results demonstrated that CS-OTA-Fe hydrogels showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus)and Gram-negative bacteria (Escherichia coli), low hemolysis rate ( © 2024 Elsevier Ltd
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