Metal-free construction of diverse 1,2,4-triazolo[1,5-a]pyridines on water

被引：0
|
作者：
Chunhua Ma [1 ]
Mengjiao Liu [1 ]
Siyu Ouyang [1 ]
Zhenwei Cui [2 ]
Jingjing Bi [1 ]
Yuqin Jiang [1 ]
Zhiguo Zhang [1 ]
机构：
[1] Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions,Ministry of Education, Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical, Henan Engineering
[2] Chongqing Aoshe Bio-chemical
来源：
Chinese Chemical Letters | 2025年 / 36卷 / 01期
关键词：
D O I：
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中图分类号：
O626.32 [氮杂苯（吡啶）族];
学科分类号：
摘要：
A transition-metal-and oxidant-free amination/cyclization reaction to access 1,2,4-triazolo[1,5-a]pyridines was realized in water by using amino diphenylphosphinate as amino source. A broad array of readily accessible N-(pyridyl)amides could be converted into the products featuring a diverse set of functional groups. The sustainable methodology was successfully applied to the late-stage functionalization of natural products and drugs.
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页码：273 / 276
页数：4
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