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Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Wuhan Natl Lab Optoelect,Coll Life Sci & Technol, Britton Chance Ctr Biomed Photon,Dept Syst Biol, Wuhan 430074, Peoples R China Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Wuhan Natl Lab Optoelect,Coll Life Sci & Technol, Britton Chance Ctr Biomed Photon,Dept Syst Biol, Wuhan 430074, Peoples R China