In situ gelling polysaccharide-based hydrogel for cell and drug delivery in tissue engineering

被引：0

作者：

20134917046890

机构：

[1] Cheng, Yixing

[2] 2,Nada, Ahmed A.

[3] Valmikinathan, Chandra M.

[4] Lee, Paul

[5] Liang, Danni

[6] Yu, Xiaojun

[7] 2,3,4,Kumbar, Sangamesh G.

来源：

Kumbar, S.G. (kumbar@uchc.edu) | 1600年 / John Wiley and Sons Inc卷 / 131期

关键词：

Injectable hydrogels have attracted a great deal of attention as cell carriers and bioactive agents in regenerative medicine due to their ability to fill complex three-dimensional (3D) tissue gaps and relative ease of in vivo administration. Polysaccharide-based hydrogels can provide microenvironments that favor tissue regeneration and biocompatibility due to their chemical similarities with native extracellular matrix components. This manuscript reports the in vitro application of an injectable chitosan-based polysaccharide hydrogel for cell and protein delivery. Crosslinked hydrogels were produced by the reaction between the amino functionality of chitosan and the aldehyde of dextran aldehyde resulting in an imine bond (Schiff's base) formation in aqueous solutions. This approach eliminated the use of additional crosslinking agents which may pose undesired side effects regarding cytotoxicity and biocompatibility. Additionally; we demonstrate versatility of the gel in terms of its fabrication; and ability to alter mechanical properties by changing the crosslinking extent due to aldehyde content. Bovine serum albumin (BSA); used as a model protein; followed a steady release pattern from the gel. BSA release was dependent on the extent of hydrogel crosslinking. Increase in crosslinking extent resulted in improved mechanical properties and sustained release of BSA. Human fetal osteoblasts encapsulated into the hydrogel showed at least 70% viability and continued to proliferate under in vitro culture. © 2013 Wiley Periodicals; Inc;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Journal article (JA)

引用

共 50 条

[21] Polysaccharide-based nanocarriers for efficient transvascular drug delivery
Zhang, Min
Ma, He
Wang, Xijie
Yu, Bing
Cong, Hailin
Shen, Youqing
JOURNAL OF CONTROLLED RELEASE, 2023, 354 : 167 - 187
[22] Polysaccharide-based responsive nanogels for controlled drug delivery
Auzely-Velty, Rachel
Jing, Jing
Hachet, Emilie
Alaimo, David
De Vlieghere, Elly
Szarpak, Anna
Jerome, Christine
De Geest, Bruno
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[23] Polysaccharide-based systems in drug and gene delivery Preface
Wang, Yanming
Wang, Peng George
ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (09) : 1121 - 1122
[24] Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
Yu, Haozhe
Wu, Wenyu
Lin, Xiang
Feng, Yun
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
[25] Recent Reports on Polysaccharide-Based Materials for Drug Delivery
Kurczewska, Joanna
POLYMERS, 2022, 14 (19)
[26] Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis
Baranov, Nicolae
Popa, Marcel
Atanase, Leonard Ionut
Ichim, Daniela Luminita
MOLECULES, 2021, 26 (09):
[27] Polysaccharide-based aerogel microspheres for oral drug delivery
Garcia-Gonzalez, C. A.
Jin, M.
Gerth, J.
Alvarez-Lorenzo, C.
Smirnova, I.
CARBOHYDRATE POLYMERS, 2015, 117 : 797 - 806
[28] Polysaccharide-based materials for cartilage tissue engineering applications
Oliveira, J. T.
Reis, R. L.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2011, 5 (06) : 421 - 436
[29] Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering
Dinoro, Jeremy
Maher, Malachy
Talebian, Sepehr
Jafarkhani, Mahboubeh
Mehrali, Mehdi
Orive, Gorka
Foroughi, Javad
Lord, Megan S.
Dolatshahi-Pirouz, Alireza
BIOMATERIALS, 2019, 214
[30] The feasibility study of an in situ marine polysaccharide-based hydrogel as the vitreous substitute
Jiang, Xiaolei
Peng, Yanfei
Yang, Chaozhong
Liu, Wanshun
Han, Baoqin
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2018, 106 (07) : 1997 - 2006

← 1 2 3 4 5 →