Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

被引：15
|
作者：
Yu, Haozhe [1 ,2 ]
Wu, Wenyu [2 ]
Lin, Xiang [3 ]
Feng, Yun [1 ,2 ]
机构：
[1] Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing, Peoples R China
[2] Peking Univ, Hosp 3, Dept Ophthalmol, Beijing, Peoples R China
[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金; 中央高校基本科研业务费专项资金资助;
关键词：
polysaccharide-based nanomaterials; polysaccharides; ocular drug delivery; nanocarriers; nano; LYCIUM-BARBARUM POLYSACCHARIDES; CHITOSAN NANOPARTICLES; IN-VIVO; HYALURONIC-ACID; MULTILAYER FILMS; QUALITY-CONTROL; TOXICITY; VITRO; BIOCOMPATIBILITY; HEMICELLULOSES;
D O I：
10.3389/fbioe.2020.601246
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.
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页数：8
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