Parametric multiple sequence alignment and phylogeny construction

被引：8
|
作者：
Fernández-Baca, David [1 ]
Seppäläinen, Timo [2 ]
Slutzki, Giora [1 ]
机构：
[1] Department of Computer Science, Iowa State University, Ames, IA 50011, United States
[2] Department of Mathematics, University of Wisconsin-Madison, Madison, WI 53706, United States
来源：
Journal of Discrete Algorithms | 2004年 / 2卷 / 2 SPEC. ISS.期
关键词：
Algorithms - Alignment - DNA - Functions - Problem solving - Sensitivity analysis - Theorem proving;
D O I：
10.1016/S1570-8667(03)00078-9
中图分类号：
学科分类号：
摘要：
Bounds are given on the size of the parameter-space decomposition induced by multiple sequence alignment problems where phylogenetic information may be given or inferred. It is shown that many of the usual formulations of these problems fall within the same integer parametric framework, implying that the number of distinct optima obtained as the parameters are varied across their ranges is polynomially bounded in the length and number of sequences. © 2003 Elsevier B.V. All rights reserved.
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页码：271 / 287
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