Bismuth- and Iron-Catalyzed Three-Component Synthesis of α-Amino Acid Derivatives: A Simple and Convenient Route to α-Arylglycines

被引：0
|
作者：
Halli J. [1 ]
Schneider A.E. [1 ]
Beisel T. [1 ]
Kramer P. [1 ]
Shemet A. [1 ]
Manolikakes G. [1 ]
机构：
[1] Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Straße 7, Frankfurt am Main
来源：
Synthesis (Germany) | 2017年 / 49卷 / 04期
关键词：
amino acids; aza-Friedel-Crafts reaction; bismuth; homogeneous catalysis; iron; multicomponent reactions;
D O I：
10.1055/s-0035-1561499
中图分类号：
学科分类号：
摘要：
Efficient bismuth- and iron-catalyzed three-component syntheses of α-arylglycines have been developed. These methods provide a general, atom-economic route to various N-protected α-arylglycines starting from readily available amides (or carbamates), glyoxalates, and (hetero)arenes with water as the only by-product. Scope and limitations of bismuth- and iron-catalyzed reactions are discussed and compared. In addition, mechanistic investigations as well as initial forays into stereoselective three-component reactions are presented. © Georg Thieme VerlagStuttgart · New York.
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收藏
页码：849 / 879
页数：30
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