Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

被引：0

作者：

Hardy J.G. ^{[1
]}

Torres-Rendon J.G. ^{[2
]}

Leal-Egaña A. ^{[1
]}

Walther A. ^{[2
]}

Schlaad H. ^{[3
]}

Cölfen H. ^{[4
]}

Scheibel T.R. ^{[1
]}

机构：

[1] Lehrstuhl Biomaterialien, Universität Bayreuth, Universitätsstraße 30, Bayreuth

[2] DWI Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen

[3] Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, Potsdam

[4] Physical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz

来源：

Cölfen, Helmut (helmut.coelfen@uni-konstanz.de) | 1600年 / MDPI AG卷 / 09期

关键词：

Biodegradable polymers; Biomaterials; Biomineralization; Bone tissue engineering; Recombinant protein; Spider silk;

D O I：

10.3390/MA9070560

中图分类号：

学科分类号：

摘要：

Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.

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