Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

被引：0
|
作者：
Hardy J.G. [1 ]
Torres-Rendon J.G. [2 ]
Leal-Egaña A. [1 ]
Walther A. [2 ]
Schlaad H. [3 ]
Cölfen H. [4 ]
Scheibel T.R. [1 ]
机构：
[1] Lehrstuhl Biomaterialien, Universität Bayreuth, Universitätsstraße 30, Bayreuth
[2] DWI Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen
[3] Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, Potsdam
[4] Physical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz
来源：
Cölfen, Helmut (helmut.coelfen@uni-konstanz.de) | 1600年 / MDPI AG卷 / 09期
关键词：
Biodegradable polymers; Biomaterials; Biomineralization; Bone tissue engineering; Recombinant protein; Spider silk;
D O I：
10.3390/MA9070560
中图分类号：
学科分类号：
摘要：
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.
引用
收藏
相关论文
共 50 条
  • [21] The Investigation from Animal Silks to Silk Protein-based Materials
    Yang, Gong-wen
    Gu, Kai
    Shao, Zheng-zhong
    ACTA POLYMERICA SINICA, 2021, 52 (01): : 16 - 28
  • [22] Engineered silk protein-based core-shell electrospun immunomodulatory fibrous scaffold for tissue regeneration with angiogenesis
    Jebakumar, Mercyjayapriya
    Pachaiyappan, Mohandass
    Ayyadurai, Niraikulam
    Kamini, Numbi Ramudu
    Radhakrishnan, Janani
    TISSUE ENGINEERING PART A, 2022, 28 : 655 - 655
  • [23] Elastic protein-based materials in tissue reconstruction
    Urry, DW
    Pattanaik, A
    BIOARTIFICIAL ORGANS: SCIENCE, MEDICINE, AND TECHNOLOGY, 1997, 831 : 32 - 46
  • [24] Development of tissue-engineered materials based on silk fibroin
    Nakazawa, Yasumoto, 1600, Society of Fiber Science and Technology (70):
  • [25] Development of Tissue-Engineered Materials Based on Silk Fibroin
    Nakazawa, Yasumoto
    SEN-I GAKKAISHI, 2014, 70 (08) : 286 - 290
  • [26] Physiochemical characteristics and bone/cartilage tissue engineering potentialities of protein-based macromolecules - A review
    Rasheed, Tahir
    Bilal, Muhammad
    Zhao, Yuping
    Raza, Ali
    Shah, Syed Zakir Hussain
    Iqbal, Hafiz M. N.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 121 : 13 - 22
  • [27] Micro-engineered biomineralized materials for bone tissue engineering
    Tan, J
    Saltzman, WM
    SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES, 2002, : 807 - 808
  • [28] Silk-Based Materials for Hard Tissue Engineering
    Neubauer, Vanessa J.
    Doebl, Annika
    Scheibel, Thomas
    MATERIALS, 2021, 14 (03) : 1 - 31
  • [29] Development of silk fibroin/nanohydroxyapatite composite hydrogels for bone tissue engineering
    Ribeiro, Marta
    de Moraes, Mariana A.
    Beppu, Marisa M.
    Garcia, Monica P.
    Fernandes, Maria H.
    Monteiro, Fernando J.
    Ferraz, Maria P.
    EUROPEAN POLYMER JOURNAL, 2015, 67 : 66 - 77
  • [30] Editorial: Advances in protein-based biomaterials for tissue engineering
    Nie, Lei
    Hou, Ruixia
    Shavandi, Amin
    Frontiers in Bioengineering and Biotechnology, 2022, 10
12345