FLAIR Hyperintense Cortical Lesions in a 4-Year-Old Child with Myelin Oligodendrocyte Glycoprotein (MOG)-Associated Encephalitis and Seizures: A Case Report

被引:0
|
作者
Bernardi, Luca [1 ]
Mussi, Nicole [1 ]
Grandinetti, Roberto [1 ]
Turco, Emanuela [1 ]
Piccolo, Benedetta [1 ]
Ormitti, Francesca [2 ]
Principi, Nicola [3 ]
Esposito, Susanna [1 ]
机构
[1] Azienda Osped Univ Parma, Pediat Clin, Dept Med & Surg, I-43126 Parma, Italy
[2] Azienda Osped Univ Parma, Unit Neuroradiol, I-43126 Parma, Italy
[3] Univ Milan, I-20122 Milan, Italy
来源
CHILDREN-BASEL | 2024年 / 11卷 / 07期
关键词
encephalitis; FLAMES; MOG antibodies; pediatric neurology; seizures; SPECTRUM; RESPONSES; DISEASE;
D O I
10.3390/children11070778
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD) is a relatively uncommon autoantibody demyelinating disorder of the central nervous system (CNS) with heterogeneous clinical manifestations and magnetic resonance imaging (MRI) findings. In recent years, a rare MOGAD subtype characterized by distinct clinical and MRI findings has been described. Seizures and cortical hyperintensities best seen on MRI T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences, associated with headache and cerebral spine fluid (CSF) pleocytosis, are the most important characteristics of this MOGAD entity that is named FLAMES (FLAIR hyperintense cortical lesions in MOG-associated encephalitis with seizures). Because of its rarity and the peculiarities of the brain damage and clinical manifestations, it can be under-recognized and confused with focal viral encephalitis, meningitis, subarachnoid hemorrhage, CNS vasculitis, or mitochondrial cytopathy. We described the case of a 4-year-old previously healthy girl who was admitted for focal-onset, tonic-clonic seizures, fever, and headache, combined with optic neuritis. MRI was characterized by FLAIR imaging showing hyperintense cortical lesions, and a mild leukocytosis in the CSF was detected. Efficacy and rapid response to steroid therapy was observed, and no recurrences of neurological problems or further seizures were reported in the following 12 months. This case report can help in understanding FLAMES characteristics in pediatrics in order to favor early diagnosis and prompt therapy.
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页数:7
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