Single-cell atlas defines distinct immune escape mechanisms in colorectal cancer

被引：0
|
作者：
Chu, Xiaojing [1 ]
Zhang, Zemin
机构：
[1] Changping Lab, Beijing, Peoples R China
来源：
NATURE CANCER | 2024年 / 5卷 / 09期
关键词：
D O I：
10.1038/s43018-024-00809-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An integrative single-cell analysis of the human colorectum reveals tumor-associated cellular alterations and regulatory pathways. Patient stratification based on cellular composition of the tumor microenvironment suggests distinct immune evasion mechanisms in colorectal cancer.
引用
收藏
页码：1292 / 1293
页数：2
相关论文
共 50 条
  • [21] An integrated single-cell atlas of blood immune cells in aging
    Filippov, Igor
    Schauser, Leif
    Peterson, Part
    NPJ AGING, 2024, 10 (01):
  • [22] An isoform-resolution transcriptomic atlas of colorectal cancer from longread single-cell sequencing
    Li, Zhongxiao
    Zhang, Bin
    Chan, Jia Jia
    Tabatabaeian, Hossein
    Tong, Qing Yun
    Chew, Xiao Hong
    Fan, Xiaonan
    Chan, Charlene
    Driguez, Patrick
    Cheong, Faith
    Wang, Shi
    Siew, Bei En
    Tan, Ian Jse-Wei
    Lee, Kai-Yin
    Lieske, Bettina
    Cheong, Wai-Kit
    Kappei, Dennis
    Tan, Ker-Kan
    Gao, Xin
    Tay, Yvonne
    CANCER RESEARCH, 2024, 84 (06)
  • [23] Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer
    Tian, Yaru
    Zhai, Xiaoyang
    Han, Anqin
    Zhu, Hui
    Yu, Jinming
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (1)
  • [24] Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer
    Steinert, Gunnar
    Schoelch, Sebastian
    Niemietz, Thomas
    Iwata, Naoki
    Garcia, Sebastian A.
    Behrens, Bianca
    Voigt, Anita
    Kloor, Matthias
    Benner, Axel
    Bork, Ulrich
    Rahbari, Nuh N.
    Buechler, Markus W.
    Stoecklein, Nikolas H.
    Weitz, Juergen
    Koch, Moritz
    CANCER RESEARCH, 2014, 74 (06) : 1694 - 1704
  • [25] Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer
    Yaru Tian
    Xiaoyang Zhai
    Anqin Han
    Hui Zhu
    Jinming Yu
    Journal of Hematology & Oncology, 12
  • [26] Single-cell transcriptomic atlas reveals immune and metabolism perturbation of depression in the pathogenesis of breast cancer
    Wu, Lingling
    Liu, Junwei
    Geng, Yimeng
    Fang, Jianwen
    Gao, Xingle
    Lai, Jianbo
    Yao, Minya
    Lu, Shaojia
    Yin, Weiwei
    Fu, Peifen
    Chen, Wei
    Hu, Shaohua
    CANCER COMMUNICATIONS, 2024, 44 (11) : 1311 - 1315
  • [27] Single-cell mtDNA heteroplasmy in colorectal cancer
    Almeida, Joao
    Alves, Joao M.
    Valecha, Monica
    Prado-Lopez, Sonia
    Alvarino, Pilar
    Fonseca, Miguel M.
    Posada, David
    Perez-Figueroa, Andres
    Cameselle-Teijeiro, Jose Manuel
    Chantada, Debora
    GENOMICS, 2022, 114 (02)
  • [28] Integrated Single-Cell Lung Cancer Atlas Revealed Distinct Fibroblast Phenotypes between LUAD and LUSC
    Hirano, Yuta
    Suzuki, Hironori
    Nakayama, Jun
    Yamamoto, Tomofumi
    Araya, Jun
    Fujita, Yu
    Yamamoto, Yusuke
    CANCER SCIENCE, 2025, 116 : 94 - 94
  • [29] Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma
    Kirschenbaum, Daniel
    Xie, Ken
    Ingelfinger, Florian
    Katzenelenbogen, Yonatan
    Abadie, Kathleen
    Look, Thomas
    Sheban, Fadi
    San Phan, Truong
    Li, Baoguo
    Zwicky, Pascale
    Yofe, Ido
    David, Eyal
    Mazuz, Kfir
    Hou, Jinchao
    Chen, Yun
    Shaim, Hila
    Shanley, Mayra
    Becker, Soeren
    Qian, Jiawen
    Colonna, Marco
    Ginhoux, Florian
    Rezvani, Katayoun
    Theis, Fabian J.
    Yosef, Nir
    Weiss, Tobias
    Weiner, Assaf
    Amit, Ido
    CELL, 2024, 187 (01) : 149 - 165.e23
  • [30] Implications of single-cell immune landscape of tumor microenvironment for the colorectal cancer diagnostics and therapy
    Alzamami, Ahmad
    MEDICAL ONCOLOGY, 2023, 40 (12)
12345