Manganese(I)-Catalyzed Direct Addition of C(sp3)-H Bonds to Aryl Isocyanates

被引：0

作者：

Liu, Hongxin ^{[1
]}

Yu, Zhichao ^{[1
]}

Li, Bin ^{[1
]}

Wang, Baiquan ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 18期

基金：

中国国家自然科学基金;

关键词：

C-H BOND; DIRECT NUCLEOPHILIC-ADDITION; CYCLIZATION DIRECT SYNTHESIS; CATALYZED DIRECT ADDITION; HETEROAROMATIC-COMPOUNDS; VERSATILE ROUTE; ORTHO-AMIDATION; MANGANESE; ACTIVATION; AMINOCARBONYLATION;

D O I：

10.1021/acs.joc.4c01581

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of C-H bonds to isocyanates catalyzed by transition metals is a highly auspicious methodology for providing synthetically and biologically important amides. However, the substrates are limited to C(sp(2))-H bonds. In this work, an efficient manganese(I)-catalyzed direct addition reaction of C(sp(3))-H bonds of 8-methylquinolines to aryl isocyanates has been developed, leading to the synthesis of various alpha-quinolinyl amide compounds in moderate to high yields. The reaction has a broad range of substrates and a good functional group tolerance. A possible mechanism is proposed based on the experimental results.

引用

页码：13429 / 13437

页数：9

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