Pd(II)-Catalyzed Direct Sulfonylation of Unactivated C(sp3)-H Bonds with Sodium Sulfinates

被引：105
|
作者：
Rao, Wei-Hao [1 ]
Zhan, Bei-Bei [1 ]
Chen, Kai [1 ]
Ling, Peng-Xiang [1 ]
Zhang, Zhuo-Zhuo [1 ]
Shi, Bing-Feng [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 14期
关键词：
C-S BOND; CATALYZED DIRECT THIOLATION; EFFICIENT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; C(SP(2))-H BONDS; TERMINAL ALKYNES; ARYL HALIDES; ARYLATION; FUNCTIONALIZATION; ALKYLATION;
D O I：
10.1021/acs.orglett.5b01634
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd(II)-catalyzed sulfonylation of unactivated C(sp(3))-H bonds with sodium arylsulfinates using an 8-aminoquinoline auxiliary is described. This reaction demonstrates excellent functional group tolerance with respect to both the caboxamide starting material and the sodium arylsulfinate coupling partner, affording a broad range of aryl alkyl sulfones. Moreover, the late-stage modification of complex molecules was achieved via this sulfonylation protocol.
引用
收藏
页码：3552 / 3555
页数：4
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