CD19 CAR-T Cell Therapy: High Efficacy in Autoimmune Diseases

被引:0
|
作者
Brudermanns, Britta
机构
关键词
D O I
10.1055/a-2313-4535
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies and systemic sclerosis often requires long-term immunosuppression. F. M & uuml;ller and colleagues now investigated the resetting of aberrant autoimmunity by deep depletion of B cells as a potential strategy to achieve a sustained drug-free remission.
引用
收藏
页码:126 / 126
页数:1
相关论文
共 50 条
  • [21] Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy
    Lihong An
    Yuehui Lin
    Biping Deng
    Zhichao Yin
    Defeng Zhao
    Zhuojun Ling
    Tong Wu
    Yongqiang Zhao
    Alex H. Chang
    Chunrong Tong
    Shuangyou Liu
    BMC Cancer, 22
  • [22] Efficacy and influencing factors of CD19 CAR-T cell therapy for children and adults with r/r B-ALL
    An, F.
    Liu, Z.
    Wu, F.
    Wang, H.
    Zhang, J.
    Cheng, F.
    Tao, Q.
    Li, Y.
    Shen, Y.
    Ruan, Y.
    Zhang, Q.
    Pan, Y.
    Zhu, W.
    Wang, W.
    Xu, H.
    Qin, H.
    Wang, Y.
    Feng, Z.
    Song, X.
    Zhai, Z.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1717 - 1717
  • [23] Genomic Drivers of Large B-Cell Lymphoma Resistance to CD19 CAR-T Therapy
    Jain, Michael D.
    Ziccheddu, Bachisio
    Coughlin, Caroline A.
    Faramand, Rawan
    Griswold, Anthony J.
    Reid, Kayla M.
    Landgren, Ola
    Locke, Frederick L.
    Maura, Francesco
    Davila, Marco L.
    Schatz, Jonathan H.
    BLOOD, 2021, 138
  • [24] CD19 CAR-T Cell Therapy Induced Immunotherapy Associated Interstitial Pneumonitis: A Case Report
    Sun, Zhuanyi
    Xie, Caiqin
    Liu, Hui
    Yuan, Xianggui
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [25] Biomarkers of outcome in patients undergoing CD19 CAR-T therapy for large B cell lymphoma
    Gong, Inna Y.
    Tran, Daisy
    Saibil, Samuel
    Laister, Rob C.
    Kuruvilla, John
    HEMASPHERE, 2024, 8 (08):
  • [26] Assessment and management of cytokine release syndrome and neurotoxicity following CD19 CAR-T cell therapy
    Chou, Cassie K.
    Turtle, Cameron J.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2020, 20 (06) : 653 - 664
  • [27] GENOMIC DRIVERS OF LARGE B-CELL LYMPHOMA RESISTANCE TO CD19 CAR-T THERAPY
    Jain, Michael
    Ziccheddu, Bachisio
    Coughlin, Caroline
    Faramand, Rawan
    Griswold, Anthony
    Reid, Kayla
    Landgren, Ola
    Locke, Frederick
    Maura, Francesco
    Davila, Marco
    Schatz, Jonathan
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A703 - A703
  • [28] Clinical Trial of CD19 CAR-T Cell Therapy with non-virus Vector System
    Takahashi, Yoshiyuki
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S3 - S3
  • [29] Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion
    Rejeski, Kai
    Perez, Ariel
    Iacoboni, Gloria
    Blumenberg, Viktoria
    Buecklein, Veit L.
    Voelkl, Simon
    Penack, Olaf
    Albanyan, Omar
    Stock, Sophia
    Mueller, Fabian
    Karschnia, Philipp
    Petrera, Agnese
    Reid, Kayla
    Faramand, Rawan
    Davila, Marco L.
    Modi, Karnav
    Dean, Erin A.
    Bachmeier, Christina
    von Bergwelt-Baildon, Michael
    Locke, Frederick L.
    Bethge, Wolfgang
    Bullinger, Lars
    Mackensen, Andreas
    Barba, Pere
    Jain, Michael D.
    Subklewe, Marion
    SCIENCE ADVANCES, 2023, 9 (38)
  • [30] CAR-T THERAPY FORCES AUTOIMMUNE DISEASES INTO REMISSION
    Ledford, Heidi
    NATURE, 2023, 624 (7992) : 483 - 484