Metal-free approach for imidazole synthesis via one-pot N-α-C(sp3)-H bond functionalization of benzylamines

被引：2
|
作者：
Kadu, Vikas D. [1 ]
Thokal, Machhindra S. [1 ]
Godase, Rajkumar K. [1 ]
Kotali, Bhagyashree C. [1 ]
Wadkar, Pooja S. [1 ]
机构：
[1] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India
来源：
RSC ADVANCES | 2024年 / 14卷 / 39期
关键词：
TETRASUBSTITUTED IMIDAZOLES; POLYSUBSTITUTED IMIDAZOLES; NITROGEN-HETEROCYCLES; EFFICIENT; ANTIBACTERIAL; CYCLIZATION; ANALOGS; DRUGS;
D O I：
10.1039/d4ra03939d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The N-alpha-C(sp(3))-H bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.
引用
收藏
页码：28332 / 28339
页数：8
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