Metal-free approach for imidazole synthesis via one-pot N-α-C(sp3)-H bond functionalization of benzylamines

被引：2

作者：

Kadu, Vikas D. ^{[1
]}

Thokal, Machhindra S. ^{[1
]}

Godase, Rajkumar K. ^{[1
]}

Kotali, Bhagyashree C. ^{[1
]}

Wadkar, Pooja S. ^{[1
]}

机构：

[1] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India

来源：

RSC ADVANCES | 2024年 / 14卷 / 39期

关键词：

TETRASUBSTITUTED IMIDAZOLES; POLYSUBSTITUTED IMIDAZOLES; NITROGEN-HETEROCYCLES; EFFICIENT; ANTIBACTERIAL; CYCLIZATION; ANALOGS; DRUGS;

D O I：

10.1039/d4ra03939d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The N-alpha-C(sp(3))-H bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.

引用

页码：28332 / 28339

页数：8

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