One-step synthesis of sugar nucleotides under optimized conditions

被引：0
|
作者：
Fujihara, Kota [1 ]
Yamamura, Hatsuo [1 ]
Miyagawa, Atsushi [1 ]
机构：
[1] Nagoya Inst Technol, Dept Life Sci & Appl Chem, Nagoya, Aichi, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 15期
关键词：
2-Chloro-1,3-dimethylimidazolinium chloride; one-step reaction; optimization; sugar nucleotide;
D O I：
10.1080/00397911.2024.2380063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sugar nucleotides are essential substrates used for synthesizing bioactive oligosaccharides in enzymatic reactions, however, their preparation via chemical and enzyme reactions is challenging. Therefore, we investigated the synthesis of sugar nucleotides under optimal conditions using a facile one-step reaction. Seven sugar nucleotides were synthesized via an optimized one-step reaction in 40-80% yield, exhibiting a preference for 1,2-trans glycoside. Moreover, a gram-scale synthesis of UDP-galactose resulted in a 46% (578 mg) yield.
引用
收藏
页码：1245 / 1251
页数：7
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