One-step synthesis of sugar nucleotides under optimized conditions

被引：0
|
作者：
Fujihara, Kota [1 ]
Yamamura, Hatsuo [1 ]
Miyagawa, Atsushi [1 ]
机构：
[1] Nagoya Inst Technol, Dept Life Sci & Appl Chem, Nagoya, Aichi, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 15期
关键词：
2-Chloro-1,3-dimethylimidazolinium chloride; one-step reaction; optimization; sugar nucleotide;
D O I：
10.1080/00397911.2024.2380063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sugar nucleotides are essential substrates used for synthesizing bioactive oligosaccharides in enzymatic reactions, however, their preparation via chemical and enzyme reactions is challenging. Therefore, we investigated the synthesis of sugar nucleotides under optimal conditions using a facile one-step reaction. Seven sugar nucleotides were synthesized via an optimized one-step reaction in 40-80% yield, exhibiting a preference for 1,2-trans glycoside. Moreover, a gram-scale synthesis of UDP-galactose resulted in a 46% (578 mg) yield.
引用
收藏
页码：1245 / 1251
页数：7
相关论文
共 50 条
  • [21] Synthesis of pogostone by one-step
    Chen, Han-Bin
    Zhou, Jiang-Tao
    Liu, Yu-Hong
    Zhang, Zhen-Biao
    Zhan, Ya-Xian
    Su, Zi-Ren
    Zeng, Hui-Fang
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 19 (02) : 172 - 175
  • [22] ONE-STEP SYNTHESIS OF (+/-)-FRONTALIN
    KONGKATHIP, N
    KONGKATHIP, B
    JOURNAL OF THE SCIENCE SOCIETY OF THAILAND, 1992, 18 (04): : 225 - 227
  • [23] One-step synthesis of isocorroles
    Nardis, Sara
    Pomarico, Giuseppe
    Fronczek, Frank R.
    Vicente, Maria Graca H.
    Paolesse, Roberto
    TETRAHEDRON LETTERS, 2007, 48 (49) : 8643 - 8646
  • [24] One-Step Synthesis of Normoftal
    A. N. Balaev
    E. V. Reshetnikov
    V. E. Fedorov
    Pharmaceutical Chemistry Journal, 2014, 48 : 49 - 50
  • [25] One-Step Synthesis of Normoftal
    Balaev, A. N.
    Reshetnikov, E. V.
    Fedorov, V. E.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (01) : 49 - 50
  • [26] One-step synthesis of diphenyhnethanes
    Wei, QY
    Luo, YG
    Zhou, M
    Tao, FY
    Zhang, GL
    SYNTHETIC COMMUNICATIONS, 2005, 35 (06) : 835 - 843
  • [27] A ONE-STEP SYNTHESIS OF DIHYDROFLAVONOLS
    MULCHANDANI, NB
    CHADHA, MS
    CHEMISTRY & INDUSTRY, 1964, (36) : 1554 - 1554
  • [28] ONE-STEP SYNTHESIS OF DODECAMETHYLCYCLOHEXASILANE
    LAGUERRE, M
    DUNOGUES, J
    CALAS, R
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (06) : 272 - 272
  • [29] ONE-STEP SYNTHESIS OF CYCLOPENTADIENYLCHLOROSILANES
    KOSHUTIN, VI
    MAKSIMOVA, LN
    EMYASHEV, VI
    SMIRNOV, VA
    ZHURNAL OBSHCHEI KHIMII, 1976, 46 (01): : 146 - 150
  • [30] One-step regioselective green synthesis of 2,3-mannoepoxy-β-cyclodextrin under aqueous conditions
    Wang, Zhi-zhong
    Jiao, Wei
    He, Guang-yun
    Lu, Run-hua
    MONATSHEFTE FUR CHEMIE, 2009, 140 (01): : 79 - 81
12345