Nickel-catalyzed reductive cross-coupling of monofluoroalkyl triflates with aryl halides for monofluoroalkylated arenes

被引：0

作者：

Li, Zhi-Heng ^{[1
]}

Peng, Hao ^{[1
]}

Zhang, Panke ^{[2
,3
]}

Hu, Yu-Ang ^{[1
]}

Pi, Chao ^{[2
,3
]}

Zhu, Cuiju ^{[1
]}

Xu, Hao ^{[1
]}

机构：

[1] Cent China Normal Univ, Minist Educ, Coll Chem, State Key Lab Green Pesticide,Engn Res Ctr Photoen, Wuhan 430079, Peoples R China

[2] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[3] Zhengzhou Univ, Coll Chem, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 18期

基金：

中国国家自然科学基金;

关键词：

C-H FLUORINATION; NUCLEOPHILIC FLUORINATION; BOND FORMATION; FLUORIDE-ION; LIGHT;

D O I：

10.1039/d4qo01033g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes. This method is characterized by mild reaction conditions, a broad substrate scope, with excellent functional group compatibility. Facile follow-up transformations highlight its utility as an appealing tool in the synthesis of pharmaceutical derivatives. Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes.

引用

页码：5010 / 5015

页数：6

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