A near-infrared light-driven Janus nanomotor for deep tumor penetration and enhanced tumor immunotherapy

被引：3
|
作者：
Ma, Ke [1 ]
Chen, Zelong [1 ]
Liang, Kai [1 ]
Pei, Yuxin [1 ]
Pei, Zhichao [1 ]
机构：
[1] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 71期
基金：
中国国家自然科学基金;
关键词：
CANCER-IMMUNOTHERAPY;
D O I：
10.1039/d4cc03445g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A near-infrared light-driven Janus nanomotor is constructed by collagenase-coated gold nanorods and chitosan-functionalized mesoporous organosilica nanoparticles with Mn2+ as the bridging ion. The nanomotors with excellent motility and collagenase activity can potently penetrate into tumors to sufficiently activate innate immune responses, significantly enhancing anti-tumor immune efficacy in vivo. A near-infrared light-driven Janus nanomotor with excellent motility and collagenase activity is constructed, which can potently penetrate into tumors and significantly enhance anti-tumor immune efficacy.
引用
收藏
页码：9550 / 9553
页数：4
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