A near-infrared light-driven Janus nanomotor for deep tumor penetration and enhanced tumor immunotherapy

被引：3
|
作者：
Ma, Ke [1 ]
Chen, Zelong [1 ]
Liang, Kai [1 ]
Pei, Yuxin [1 ]
Pei, Zhichao [1 ]
机构：
[1] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 71期
基金：
中国国家自然科学基金;
关键词：
CANCER-IMMUNOTHERAPY;
D O I：
10.1039/d4cc03445g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A near-infrared light-driven Janus nanomotor is constructed by collagenase-coated gold nanorods and chitosan-functionalized mesoporous organosilica nanoparticles with Mn2+ as the bridging ion. The nanomotors with excellent motility and collagenase activity can potently penetrate into tumors to sufficiently activate innate immune responses, significantly enhancing anti-tumor immune efficacy in vivo. A near-infrared light-driven Janus nanomotor with excellent motility and collagenase activity is constructed, which can potently penetrate into tumors and significantly enhance anti-tumor immune efficacy.
引用
收藏
页码：9550 / 9553
页数：4
相关论文
共 50 条
  • [21] Tumor microenvironment-activated and near-infrared light-driven free radicals amplifier for tetra-modal cancer imaging and synergistic treatment
    Fan, Yadi
    Shi, Jingyu
    Zhang, Ruolin
    Tian, Feng
    Zhang, Yu
    Zhang, Li
    Yang, Mo
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2025, 689
  • [22] NIR powered Janus nanocarrier for deep tumor penetration
    Jiao, Xiangyu
    Wang, Zemin
    Xiu, Jidong
    Dai, Wenhao
    Zhao, Liang
    Xu, Tailin
    Du, Xin
    Wen, Yongqiang
    Zhang, Xueji
    APPLIED MATERIALS TODAY, 2020, 18
  • [23] Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
    Jian You
    Peizun Zhang
    Fuqiang Hu
    Yongzhong Du
    Hong Yuan
    Jiang Zhu
    Zuhua Wang
    Jialin Zhou
    Chun Li
    Pharmaceutical Research, 2014, 31 : 554 - 565
  • [24] Near-infrared-light induced nanoparticles with enhanced tumor tissue penetration and intelligent drug release
    Zhang, Yapei
    Liu, Yang
    Gao, Xuefeng
    Li, Xiaomin
    Niu, Xiaoyan
    Yuan, Zhi
    Wang, Wei
    ACTA BIOMATERIALIA, 2019, 90 : 314 - 323
  • [25] Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
    You, Jian
    Zhang, Peizun
    Hu, Fuqiang
    Du, Yongzhong
    Yuan, Hong
    Zhu, Jiang
    Wang, Zuhua
    Zhou, Jialin
    Li, Chun
    PHARMACEUTICAL RESEARCH, 2014, 31 (03) : 554 - 565
  • [26] Near-infrared-II photocharging nanozyme for enhanced tumor immunotherapy
    Li, Anshuo
    Chu, Shuzhen
    Yuan, Meng
    Zhang, Jinhui
    Liu, Hengrui
    Zhu, Yuhui
    Xu, Jingyi
    Jiang, Xinquan
    Xue, Weili
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2024, 676 : 783 - 794
  • [27] Near-Infrared Light-Driven Controllable Motions of Gold-Hollow-Microcone Array
    Chen, Hongxu
    Zhao, Qilong
    Wang, Yunlong
    Mu, Shilin
    Cui, Huanqing
    Wang, Juan
    Kong, Tengfei
    Du, Xuemin
    ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (17) : 15927 - 15935
  • [28] Near-Infrared Light-Driven Photoredox Catalysis by Transition-Metal-Complex Nanodots
    Wang, Lele
    Sa, Rongjian
    Wei, Yingcong
    Ma, Xiongfeng
    Lu, Chenggang
    Huang, Haowei
    Fron, Eduard
    Liu, Ming
    Wang, Wei
    Huang, Shuping
    Hofkens, Johan
    Roeffaers, Maarten B. J.
    Wang, Yan-jie
    Wang, Junhui
    Long, Jinlin
    Fu, Xianzhi
    Yuan, Rusheng
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (39)
  • [29] Engineered Extracellular Vesicles to Enhance Antigen Presentation for Boosting Light-Driven Tumor Immunotherapy
    Li, Xuyu
    He, Shuaicheng
    Luo, Ban
    Li, Puze
    Chen, Xue
    Wu, Meichan
    Song, Cheng
    Liu, Chao
    Yang, Tian
    Zhang, Xiaojuan
    Yang, Xiangliang
    Hu, Jun
    SMALL, 2023, 19 (49)
  • [30] Near-Infrared Light-Enhanced Generation of Hydroxyl Radical for Cancer Immunotherapy
    Zhang, Qianqian
    Li, Yang
    Jiang, Chunhuan
    Sun, Wenbo
    Tao, Jingwei
    Lu, Lehui
    ADVANCED HEALTHCARE MATERIALS, 2023, 12 (28)
12345