Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights

被引：0

作者：

Bhardwaj, Anisha ^{[1
]}

Dubey, Amit ^{[2
,3
]}

Tufail, Aisha ^{[3
]}

Tufail, Nasir ^{[4
]}

Kumar, Manish ^{[1
]}

Garg, Sapana ^{[1
]}

机构：

[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India

[2] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Pharmacol, Chennai 600077, Tamil Nadu, India

[3] Quanta Calculus, Computat Chem & Drug Discovery Div, Greater Noida 201310, Uttar Pradesh, India

[4] Allahabad State Univ, Dept Zool, Prayagraj 211002, Uttar Pradesh, India

来源：

FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 21期

关键词：

anti-malarial agents; characterization; computational insights; organotellurium; synthesis; thiophene-based complexes; TRANSITION-METAL-COMPLEXES; SCHIFF-BASE COMPLEXES; NATURAL COMPOUNDS; ELUCIDATION; EXPLORATION; LIGANDS; CHYMASE;

D O I：

10.1080/17568919.2024.2401310

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes. Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies. Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.

引用

页码：2263 / 2283

页数：21

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