Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights

被引：0
|
作者：
Bhardwaj, Anisha [1 ]
Dubey, Amit [2 ,3 ]
Tufail, Aisha [3 ]
Tufail, Nasir [4 ]
Kumar, Manish [1 ]
Garg, Sapana [1 ]
机构：
[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India
[2] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Pharmacol, Chennai 600077, Tamil Nadu, India
[3] Quanta Calculus, Computat Chem & Drug Discovery Div, Greater Noida 201310, Uttar Pradesh, India
[4] Allahabad State Univ, Dept Zool, Prayagraj 211002, Uttar Pradesh, India
来源：
FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 21期
关键词：
anti-malarial agents; characterization; computational insights; organotellurium; synthesis; thiophene-based complexes; TRANSITION-METAL-COMPLEXES; SCHIFF-BASE COMPLEXES; NATURAL COMPOUNDS; ELUCIDATION; EXPLORATION; LIGANDS; CHYMASE;
D O I：
10.1080/17568919.2024.2401310
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes. Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies. Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.
引用
收藏
页码：2263 / 2283
页数：21
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