Optimization and scale-up of the spray drying process for Euglena gracilis

被引:0
|
作者
Zhang, Kaikai [1 ]
Wan, Minxi [1 ]
Bai, Wenmin [2 ]
Bao, Zhengxu [2 ]
Duan, Xingbo [2 ]
Wang, Weiliang [1 ]
Fan, Fei [1 ]
Li, Yuanguang [1 ]
机构
[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[2] Baoshan Zeyuan Algae Hlth Technol Co Ltd, Baoshan 678208, Peoples R China
关键词
Spray drying; Pilot-scale; Production-scale; Scale-up; E; gracilis; HAEMATOCOCCUS-PLUVIALIS; ENCAPSULATION;
D O I
10.1016/j.algal.2024.103640
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The study presents a spray drying process for Euglena gracilis. Concentrate obtained by a disc centrifuge was used as the starting material. The process was established and scaled up using pilot and production-scale spray drying towers. Optimal conditions for the pilot scale included an inlet temperature of 200 degrees C, an outlet temperature of 85 degrees C, and a solid mass fraction of E. gracilis mud of 12 %. Key parameters influencing E. gracilis powder physicochemical indexes were identified by correlation analysis as drying time for droplets (Tdrying), which can be adjusted by the outlet air temperature, the Peclet number for mass (Pemass), and heat (Peheat), and the evaporation rate (dwdt ), all of which can be adjusted by the outlet temperature. The process was successfully scaled up by optimizing the outlet temperature, achieving a productivity of 36.63 kg & sdot;h- 1 and a yield of 98.35 %. This work offers a commercially viable method for large-scale E. gracilis powder production.
引用
收藏
页数:9
相关论文
共 50 条
  • [31] Scale-up Fenton process: study and optimization in piggery wastewater treatment
    Zarate-Guzman, Ana, I
    Warren-Vega, Walter M.
    Romero-Cano, Luis A.
    Cardenas-Mijangos, Jesus
    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2021, 96 (02) : 341 - 348
  • [32] Spray drying with a two-fluid nozzle to produce fine particles: Atomization, scale-up, and modeling
    Kemp, I. C.
    Hartwig, T.
    Herdman, R.
    Hamilton, P.
    Bisten, A.
    Bermingham, S.
    DRYING TECHNOLOGY, 2016, 34 (10) : 1243 - 1252
  • [33] Process optimization and scale-up challenges in the development of a large-scale phase III manufacturing process
    Goodrick, Jason
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [34] Optimization and scale-up of pharmaceutical syntheses
    Les, Andrzei
    Szelejewski, Wieslaw
    PRZEMYSL CHEMICZNY, 2007, 86 (12): : 1174 - 1177
  • [35] Optimization and Scale-Up for Polymer Extrusion
    Nastaj, Andrzej
    Wilczynski, Krzysztof
    POLYMERS, 2021, 13 (10)
  • [36] Surmounting the Challenges of Process Scale-Up
    McHugh, Tara
    Voit, Dan
    FOOD TECHNOLOGY, 2019, 73 (04) : 130 - 133
  • [37] Production scale-up and process validation
    Boedeker, BGD
    GENETIC ENGINEER AND BIOTECHNOLOGIST, 1995, 15 (04): : 277 - 279
  • [38] SYNTHANE PROCESS READY FOR SCALE-UP
    WEISS, AJ
    HYDROCARBON PROCESSING, 1978, 57 (06): : 125 - 129
  • [39] SCALE-UP OF FINGAL GLASSMAKING PROCESS
    ELLIOT, MN
    GROVER, JR
    CHEMICAL AND PROCESS ENGINEERING, 1966, 47 (03): : 105 - &
  • [40] Kneader scale-up and process design
    Hace, Iztok
    INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2011, 57 (5-8): : 465 - 475