Optimization and scale-up of the spray drying process for Euglena gracilis

被引:0
|
作者
Zhang, Kaikai [1 ]
Wan, Minxi [1 ]
Bai, Wenmin [2 ]
Bao, Zhengxu [2 ]
Duan, Xingbo [2 ]
Wang, Weiliang [1 ]
Fan, Fei [1 ]
Li, Yuanguang [1 ]
机构
[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[2] Baoshan Zeyuan Algae Hlth Technol Co Ltd, Baoshan 678208, Peoples R China
关键词
Spray drying; Pilot-scale; Production-scale; Scale-up; E; gracilis; HAEMATOCOCCUS-PLUVIALIS; ENCAPSULATION;
D O I
10.1016/j.algal.2024.103640
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The study presents a spray drying process for Euglena gracilis. Concentrate obtained by a disc centrifuge was used as the starting material. The process was established and scaled up using pilot and production-scale spray drying towers. Optimal conditions for the pilot scale included an inlet temperature of 200 degrees C, an outlet temperature of 85 degrees C, and a solid mass fraction of E. gracilis mud of 12 %. Key parameters influencing E. gracilis powder physicochemical indexes were identified by correlation analysis as drying time for droplets (Tdrying), which can be adjusted by the outlet air temperature, the Peclet number for mass (Pemass), and heat (Peheat), and the evaporation rate (dwdt ), all of which can be adjusted by the outlet temperature. The process was successfully scaled up by optimizing the outlet temperature, achieving a productivity of 36.63 kg & sdot;h- 1 and a yield of 98.35 %. This work offers a commercially viable method for large-scale E. gracilis powder production.
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页数:9
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