Pharmacological Features and Therapeutic Implications of Plumbagin in Cancer and Metabolic Disorders: A Narrative Review

被引:0
|
作者
Sharma, Bhoomika [1 ]
Dhiman, Chitra [1 ]
Hasan, Gulam Mustafa [2 ]
Shamsi, Anas [3 ]
Hassan, Md. Imtiyaz [4 ]
机构
[1] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India
[2] Prince Sattam Bin Abdulaziz Univ, Coll Med, Dept Basic Med Sci, Alkharj 11942, Saudi Arabia
[3] Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, POB 346, Ajman, U Arab Emirates
[4] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India
关键词
plumbagin; natural products; anticancer; anti-inflammatory; apoptosis; antioxidant; cardiovascular disease; neurodegenerative diseases; CELL-CYCLE ARREST; BREAST-CANCER; PROSTATE-CANCER; HEPATOCELLULAR-CARCINOMA; MEDIATED APOPTOSIS; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; THIOREDOXIN REDUCTASE; INDUCED NEUROTOXICITY; ENDOCRINE-RESISTANCE;
D O I
10.3390/nu16173033
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Plumbagin (PLB) is a naphthoquinone extracted from Plumbago indica. In recent times, there has been a growing body of evidence suggesting the potential importance of naphthoquinones, both natural and artificial, in the pharmacological world. Numerous studies have indicated that PLB plays a vital role in combating cancers and other disorders. There is substantial evidence indicating that PLB may have a significant role in the treatment of breast cancer, brain tumours, lung cancer, hepatocellular carcinoma, and other conditions. Moreover, its potent anti-oxidant and anti-inflammatory properties offer promising avenues for the treatment of neurodegenerative and cardiovascular diseases. A number of studies have identified various pathways that may be responsible for the therapeutic efficacy of PLB. These include cell cycle regulation, apoptotic pathways, ROS induction pathways, inflammatory pathways, and signal transduction pathways such as PI3K/AKT/mTOR, STAT3/PLK1/AKT, and others. This review aims to provide a comprehensive analysis of the diverse pharmacological roles of PLB, examining the mechanisms through which it operates and exploring its potential applications in various medical conditions. In addition, we have conducted a review of the various formulations that have been reported in the literature with the objective of enhancing the efficacy of the compound. However, the majority of the reviewed data are based on in vitro and in vivo studies. To gain a comprehensive understanding of the safety and efficacy of PLB in humans and to ascertain its potential integration into therapeutic regimens for cancer and chronic diseases, rigorous clinical trials are essential. Finally, by synthesizing current research and identifying gaps in knowledge, this review seeks to enhance our understanding of PLB and its therapeutic prospects, paving the way for future studies and clinical applications.
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页数:32
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