Pharmacological Features and Therapeutic Implications of Plumbagin in Cancer and Metabolic Disorders: A Narrative Review

被引:0
|
作者
Sharma, Bhoomika [1 ]
Dhiman, Chitra [1 ]
Hasan, Gulam Mustafa [2 ]
Shamsi, Anas [3 ]
Hassan, Md. Imtiyaz [4 ]
机构
[1] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India
[2] Prince Sattam Bin Abdulaziz Univ, Coll Med, Dept Basic Med Sci, Alkharj 11942, Saudi Arabia
[3] Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, POB 346, Ajman, U Arab Emirates
[4] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India
关键词
plumbagin; natural products; anticancer; anti-inflammatory; apoptosis; antioxidant; cardiovascular disease; neurodegenerative diseases; CELL-CYCLE ARREST; BREAST-CANCER; PROSTATE-CANCER; HEPATOCELLULAR-CARCINOMA; MEDIATED APOPTOSIS; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; THIOREDOXIN REDUCTASE; INDUCED NEUROTOXICITY; ENDOCRINE-RESISTANCE;
D O I
10.3390/nu16173033
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Plumbagin (PLB) is a naphthoquinone extracted from Plumbago indica. In recent times, there has been a growing body of evidence suggesting the potential importance of naphthoquinones, both natural and artificial, in the pharmacological world. Numerous studies have indicated that PLB plays a vital role in combating cancers and other disorders. There is substantial evidence indicating that PLB may have a significant role in the treatment of breast cancer, brain tumours, lung cancer, hepatocellular carcinoma, and other conditions. Moreover, its potent anti-oxidant and anti-inflammatory properties offer promising avenues for the treatment of neurodegenerative and cardiovascular diseases. A number of studies have identified various pathways that may be responsible for the therapeutic efficacy of PLB. These include cell cycle regulation, apoptotic pathways, ROS induction pathways, inflammatory pathways, and signal transduction pathways such as PI3K/AKT/mTOR, STAT3/PLK1/AKT, and others. This review aims to provide a comprehensive analysis of the diverse pharmacological roles of PLB, examining the mechanisms through which it operates and exploring its potential applications in various medical conditions. In addition, we have conducted a review of the various formulations that have been reported in the literature with the objective of enhancing the efficacy of the compound. However, the majority of the reviewed data are based on in vitro and in vivo studies. To gain a comprehensive understanding of the safety and efficacy of PLB in humans and to ascertain its potential integration into therapeutic regimens for cancer and chronic diseases, rigorous clinical trials are essential. Finally, by synthesizing current research and identifying gaps in knowledge, this review seeks to enhance our understanding of PLB and its therapeutic prospects, paving the way for future studies and clinical applications.
引用
收藏
页数:32
相关论文
共 50 条
  • [21] Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
    Jha, Niraj Kumar
    Chen, Wei-Chih
    Kumar, Sanjay
    Dubey, Rajni
    Tsai, Lung-Wen
    Kar, Rohan
    Jha, Saurabh Kumar
    Gupta, Piyush Kumar
    Sharma, Ankur
    Gundamaraju, Rohit
    Pant, Kumud
    Mani, Shalini
    Singh, Sandeep Kumar
    Maccioni, Ricardo B.
    Datta, Tirtharaj
    Singh, Sachin Kumar
    Gupta, Gaurav
    Prasher, Parteek
    Dua, Kamal
    Dey, Abhijit
    Sharma, Charu
    Mughal, Yasir Hayat
    Ruokolainen, Janne
    Kesari, Kavindra Kumar
    Ojha, Shreesh
    OPEN BIOLOGY, 2022, 12 (03)
  • [22] The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications
    Zhuoya Jiao
    Yunxia Pan
    Fengyuan Chen
    Molecular Diagnosis & Therapy, 2023, 27 : 349 - 369
  • [23] The influence of eating behavior on eating disorders and metabolic syndrome: A narrative review
    Araujo, Luis Felipe Castro
    Carvalho, Felipe dos Santos Nascimento
    Gomes, Gleyzangela Muniz
    Pereira, Isabella Cristina Loiola de Moraes
    Pereira, Thais da Conceicao Tavares
    Macedo, Michel Monteiro
    Amorim, Carlos Eduardo Neves
    RBONE-REVISTA BRASILEIRA DE OBESIDADE NUTRICAO E EMAGRECIMENTO, 2024, 18 (115): : 873 - 879
  • [24] IBUPROFEN - REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY IN RHEUMATIC DISORDERS
    DAVIES, EF
    AVERY, GS
    DRUGS, 1971, 2 (05) : 416 - &
  • [25] Metabolic remodeling in cancer and senescence and its therapeutic implications
    Kim, Yeonju
    Jang, Yeji
    Kim, Mi-Sung
    Kang, Chanhee
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2024, 35 (08): : 732 - 744
  • [26] Effect of Ketogenic Diet on Obesity and Other Metabolic Disorders: Narrative Review
    Baylie, Temesgen
    Ayelgn, Tiget
    Tiruneh, Markeshaw
    Tesfa, Kibur Hunie
    DIABETES METABOLIC SYNDROME AND OBESITY, 2024, 17 : 1391 - 1401
  • [27] Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review
    Christelle Nguyen
    Savouret, Jean-Francois
    Widerak, Magdalena
    Corvol, Marie-Therese
    Rannou, Francois
    NUTRIENTS, 2017, 9 (01):
  • [28] A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications
    Sedighzadeh, Sahar Sadat
    Khoshbin, Amin Pastaki
    Razi, Sepideh
    Keshavarz-Fathi, Mahsa
    Rezaei, Nima
    TRANSLATIONAL LUNG CANCER RESEARCH, 2021, 10 (04) : 1889 - 1916
  • [29] Galvanic Skin Response Features in Psychiatry and Mental Disorders: A Narrative Review
    Markiewicz, Renata
    Markiewicz-Gospodarek, Agnieszka
    Dobrowolska, Beata
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 19 (20)
  • [30] Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy
    Giacomini, Isabella
    Gianfanti, Federico
    Desbats, Maria Andrea
    Orso, Genny
    Berretta, Massimiliano
    Prayer-Galetti, Tommaso
    Ragazzi, Eugenio
    Cocetta, Veronica
    FRONTIERS IN ONCOLOGY, 2021, 11