Convenient synthesis and characterization of new 1,3,4-thiadiazoles and thiazoles incorporating thiophene moiety

被引：0
|
作者：
Helmy, Mirna T. [1 ]
Kamel, Monica G. [1 ]
Mikhail, Madonna S. [1 ]
Saleh, Fatma M. [1 ]
Hassaneen, Hamdi M. [1 ]
Erian, Ayman W. [1 ]
Teleb, Mohamed A. Mohamed [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
来源：
ARKIVOC | 2024年
关键词：
1; 3; 4-Thiadiazoles; pyrazole; methyl hydrazinecarbodithioate; thiazoles; cycloaddition reaction; HYDRAZONOYL HALIDES; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTICANCER; CHEMISTRY; BROMIDE; REGIOSELECTIVITY; PYRAZOLINES; NITROGEN;
D O I：
10.24820/ark.5550190.p012.207
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of substituted acetylpyrazole with methyl hydrazinecarbodithioate using hydrochloric acid as a catalyst in absolute ethanol afforded methyl 2-(1-(1H-pyrazol-4-yl)ethylidene)hydrazinecarbodithioate H-pyrazol-4-yl)ethylidene)hydrazinecarbodithioate derivative. Refluxing of the latter product with hydrazonoyl halides in absolute ethanol in the presence of triethylamine afforded the corresponding 1,3,4-thiadiazoles. Heating the same acetylpyrazole with hydrazinecarbothioamide in refluxing ethanol using hydrochloric acid as a catalyst afforded 2-(1-(1H-pyrazol-4- H-pyrazol-4- yl)ethylidene)hydrazinecarbothioamide derivative. The reaction of the latter compound with omega- bromoacetophenone derivatives in absolute ethanol at reflux afforded the corresponding thiazole derivatives.
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页数：12
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